{"id":"W3129455830","doi":"10.1101/2021.02.22.432349","title":"Ribosomes in RNA granules are stalled on mRNA sequences that are consensus sites for FMRP association","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Azrieli Foundation; Canadian Institutes of Health Research; Queen's University Belfast; Queen's University; McGill University","keywords":"Polysome; Ribosome profiling; Ribosome; Biology; Messenger RNA; Translation (biology); RNA; Cell biology; Protein biosynthesis; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405852,0.0003153873,0.0002239965,0.0004013278,0.0002752828,0.0003548752,0.00014979,0.0003163081,0.00326193],"category_scores_gemma":[0.0002873366,0.0001867423,0.0001578638,0.0002115811,0.0002622658,0.0001749264,0.0002500539,0.0002984853,0.001264364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002915471,"about_ca_system_score_gemma":0.00009327553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006762068,"about_ca_topic_score_gemma":0.0008525134,"domain_scores_codex":[0.9999216,0.000006739052,0.000004641513,0.00002516852,0.00002155876,0.00002033466],"domain_scores_gemma":[0.9998742,0.00003158389,0.00003797737,0.00001733163,0.00001450991,0.00002427489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007523689,0.000008275416,0.001030962,0.00003337217,0.000006086931,0.0001263063,0.00002545077,0.00006695404,0.9968099,0.0001430173,0.0002005309,0.001473875],"study_design_scores_gemma":[0.00001369642,0.00006916014,0.0774305,0.00001499766,0.00001567826,0.0005547232,0.00008932711,0.00202501,0.9168612,0.0003447148,0.002573293,0.000007849882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918528,0.0006936151,0.005008867,0.00006917911,0.00004444791,0.000008897691,0.0005137553,0.0002573318,0.001551061],"genre_scores_gemma":[0.9886747,0.0002883477,0.003310057,0.00003375766,0.00002722158,0.00001582333,0.001856612,0.0001375511,0.005655963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00326193,"threshold_uncertainty_score":0.01091224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01895431292399497,"score_gpt":0.2271607649449402,"score_spread":0.2082064520209452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}