{"id":"W3129481113","doi":"10.1038/s41467-021-21365-3","title":"Non-CG methylation and multiple histone profiles associate child abuse with immune and small GTPase dysregulation","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Heart Institute; Centre Hospitalier Universitaire Sainte-Justine; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research; CIHR Skin Research Training Centre; Fondation de France; Fondation pour la Recherche Médicale; Government of Canada; Fondation Brain Canada; Fondation Fyssen; American Foundation for Suicide Prevention","keywords":"Epigenetics; DNA methylation; Context (archaeology); Histone; Biology; Chromatin; Transcriptome; Small GTPase; Epigenomics; Genetics; Neuroscience; Gene; Gene expression; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001430445,0.0002324751,0.0002357244,0.0004574426,0.0002369898,0.0003242506,0.0001342881,0.0002586445,0.00244733],"category_scores_gemma":[0.0006036855,0.0001424407,0.0001799787,0.0004264709,0.000336065,0.0001671839,0.0004333102,0.000369729,0.0001248199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273127,"about_ca_system_score_gemma":0.0001070834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001569376,"about_ca_topic_score_gemma":0.002692057,"domain_scores_codex":[0.9998448,0.00003446902,0.00001096086,0.00004971839,0.0000260264,0.00003406319],"domain_scores_gemma":[0.9996669,0.00003885227,0.0001827658,0.00003645624,0.00002170481,0.0000532656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007040999,0.00005548602,0.9116765,0.00007758605,0.0002182487,0.0008643213,0.00057278,0.0001047877,0.0738421,0.0002514795,0.000229499,0.01140316],"study_design_scores_gemma":[0.000001163594,0.00003926574,0.9961402,0.00000659028,0.00002212436,0.001021434,0.0001666955,0.00008854742,0.00214827,0.0001300572,0.0002325876,0.000002991404],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981759,0.000590234,0.0003659274,0.00007880812,0.000004291313,0.0000038328,0.0002565255,0.000008812553,0.000515665],"genre_scores_gemma":[0.9988914,0.000339029,0.0002634862,0.00002662375,0.000005043772,0.000004759489,0.000147074,0.000004692918,0.0003179035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00244733,"threshold_uncertainty_score":0.008187175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009768162428364074,"score_gpt":0.2658787262958482,"score_spread":0.2561105638674841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}