{"id":"W3129513862","doi":"10.1371/journal.pgen.1009378","title":"RanBP2/Nup358 enhances miRNA activity by sumoylating Argonautes","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fujian Medical University","keywords":"Biology; Computational biology; microRNA; Argonaute; Bioinformatics; Genetics; RNA; RNA interference; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242335,0.0003567959,0.0002072518,0.000185087,0.000145523,0.0002884092,0.0002219219,0.0002243721,0.001237346],"category_scores_gemma":[0.0001666909,0.0001468961,0.0002209423,0.00007979406,0.0002406734,0.0001491151,0.0003099316,0.0003074639,0.0004658477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001783956,"about_ca_system_score_gemma":0.0001079038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008973,"about_ca_topic_score_gemma":0.0004959184,"domain_scores_codex":[0.9997945,0.00005918582,0.00002104431,0.00004195779,0.00005002379,0.00003320736],"domain_scores_gemma":[0.9998724,0.00002411807,0.00003671889,0.00001860063,0.00001171661,0.00003637364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007485351,0.000008487958,0.00006161717,0.00001094134,0.000002204799,0.00003173877,0.000006181443,0.00002677949,0.9993809,0.00004434311,0.00001397105,0.0003379893],"study_design_scores_gemma":[0.00001012541,0.0001242038,0.00143051,0.000002361535,0.000004911816,0.0001583202,0.000009087261,0.0007031137,0.9961876,0.00003158731,0.001335104,0.000003128674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949011,0.0008344805,0.002324479,0.00008124125,0.00002580423,0.0000126741,0.0001157747,0.0001288298,0.001575625],"genre_scores_gemma":[0.99674,0.0002210599,0.001471652,0.00002070024,0.000006793964,0.00001054915,0.0001578028,0.00002834519,0.001342992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001237346,"threshold_uncertainty_score":0.004139304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01106216014656424,"score_gpt":0.2424420329481991,"score_spread":0.2313798728016349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}