{"id":"W3129515331","doi":"10.1016/j.omto.2021.02.009","title":"Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Winship Cancer Institute; National Cancer Institute; National Institutes of Health; Genentech; AstraZeneca; Oncolytics Biotech; Minneapolis Medical Research Foundation; Bristol-Myers Squibb; GlaxoSmithKline; Multiple Myeloma Research Foundation; American Cancer Society","keywords":"Oncolytic virus; Herpes simplex virus; Tropism; Virus; Biology; Virology; Viral replication; Cell culture; Cancer cell; Cancer research; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004718655,0.0003744913,0.0004285128,0.0001998486,0.00006475753,0.00008976589,0.0003035957,0.000347239,0.00007722938],"category_scores_gemma":[0.0000818534,0.0004092467,0.0001359198,0.0005675967,0.0001484317,0.00001017518,0.0002068878,0.0002794556,0.00001532258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001379723,"about_ca_system_score_gemma":0.0005500871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006251592,"about_ca_topic_score_gemma":0.001266965,"domain_scores_codex":[0.997323,0.0004100527,0.000442943,0.0007516708,0.0003721682,0.0007001904],"domain_scores_gemma":[0.9987999,0.00006246155,0.00009018038,0.0007294104,0.0001224297,0.000195685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002107074,0.0004280719,0.0001990661,0.00002680667,0.00007031097,0.00053835,0.0001204773,0.0004322926,0.9497321,0.00001023177,0.0001175357,0.04621765],"study_design_scores_gemma":[0.003451336,0.00101976,0.0003183551,0.00002870692,0.000007556527,0.00002424826,0.00007397593,0.0004639484,0.9549829,0.0001768915,0.0390252,0.0004270606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934683,0.004622838,0.0001993004,0.0002738509,0.00009630814,0.0005301562,0.00003702699,0.00001937553,0.0007528455],"genre_scores_gemma":[0.9928354,0.003712601,0.0006066869,0.002044972,0.0001019315,0.00007779367,0.00005120978,0.00009845197,0.0004709297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04579059,"threshold_uncertainty_score":0.999836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486338766277624,"score_gpt":0.2949697748991098,"score_spread":0.2801063872363336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}