{"id":"W3129515331","doi":"10.1016/j.omto.2021.02.009","title":"Oncolytic herpes simplex virus infects myeloma cells in vitro and in vivo","year":2021,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Winship Cancer Institute; National Cancer Institute; National Institutes of Health; Genentech; AstraZeneca; Oncolytics Biotech; Minneapolis Medical Research Foundation; Bristol-Myers Squibb; GlaxoSmithKline; Multiple Myeloma Research Foundation; American Cancer Society","keywords":"Oncolytic virus; Herpes simplex virus; Tropism; Virus; Biology; Virology; Viral replication; Cell culture; Cancer cell; Cancer research; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003797055,0.0004032401,0.0003184176,0.0002716514,0.0001988632,0.0005117516,0.0002139004,0.0003364349,0.001371612],"category_scores_gemma":[0.0002632298,0.0001893154,0.0002794573,0.0002503452,0.0001629598,0.0002756962,0.0002556757,0.0007904115,0.000706168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004648079,"about_ca_system_score_gemma":0.0003317872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002272952,"about_ca_topic_score_gemma":0.002267175,"domain_scores_codex":[0.9995952,0.00007991323,0.0000371189,0.00007151036,0.0001349597,0.0000811943],"domain_scores_gemma":[0.9998111,0.00006801363,0.0000317271,0.00003640507,0.00002737881,0.00002535504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001431192,0.00007872355,0.0008592827,0.0001189708,0.00002248421,0.00004587772,0.00006543431,0.0002349787,0.9910931,0.0003265961,0.0003675442,0.006643989],"study_design_scores_gemma":[0.00003169954,0.0009887061,0.006365727,0.00002171892,0.00003250231,0.0003586068,0.00007048092,0.002183698,0.9786391,0.0003056219,0.01099117,0.00001093004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9350938,0.02107363,0.02988805,0.0005286457,0.0003284048,0.0001968124,0.003005516,0.0004041294,0.009480965],"genre_scores_gemma":[0.9693018,0.009314853,0.01135331,0.0002067372,0.00006668706,0.0001148623,0.00235487,0.00005442404,0.007232448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002272952,"threshold_uncertainty_score":0.004588544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486338766277624,"score_gpt":0.2949697748991098,"score_spread":0.2801063872363336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}