{"id":"W3129561386","doi":"10.1158/1538-7445.sabcs20-gs3-00","title":"Abstract GS3-00: First results from a phase III randomized clinical trial of standard adjuvant endocrine therapy (ET) +/- chemotherapy (CT) in patients (pts) with 1-3 positive nodes, hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) < 25: SWOG S1007 (RxPonder)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Oncology; Anthracycline; Breast cancer; Taxane; Randomized controlled trial; Gynecology; Proportional hazards model; Clinical endpoint; Sentinel lymph node; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002703379,0.002084014,0.001904621,0.0004786209,0.0003815992,0.001265459,0.001452102,0.001651138,0.02419031],"category_scores_gemma":[0.002180885,0.000384776,0.002323199,0.0006721312,0.001537043,0.001088388,0.0005658357,0.003558324,0.002332215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001176361,"about_ca_system_score_gemma":0.002173788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001554827,"about_ca_topic_score_gemma":0.005085069,"domain_scores_codex":[0.9991692,0.0005502607,0.00003332662,0.00009022841,0.00006602404,0.00009100469],"domain_scores_gemma":[0.9986916,0.0003366101,0.0002274892,0.00008979316,0.00006058288,0.0005938445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9481239,0.006701779,0.001336199,0.000899089,0.001606535,0.00007292027,0.00005997835,0.0007350955,0.003417558,0.0002922912,0.01060269,0.026152],"study_design_scores_gemma":[0.9459494,0.04739527,0.002816529,0.00006711156,0.0007228148,0.00004346391,0.00002891899,0.000273919,0.000375703,0.0003156254,0.001994591,0.00001671273],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298198,0.01313709,0.001438101,0.008355992,0.001812919,0.008349575,0.02035459,0.0009100682,0.01582183],"genre_scores_gemma":[0.9447576,0.004544111,0.003250862,0.009530776,0.001157195,0.006760269,0.01657397,0.0001901952,0.01323503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02419031,"threshold_uncertainty_score":0.08092463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148298831501875,"score_gpt":0.3874085147198776,"score_spread":0.3459255264048589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}