{"id":"W3129561386","doi":"10.1158/1538-7445.sabcs20-gs3-00","title":"Abstract GS3-00: First results from a phase III randomized clinical trial of standard adjuvant endocrine therapy (ET) +/- chemotherapy (CT) in patients (pts) with 1-3 positive nodes, hormone receptor-positive (HR+) and HER2-negative (HER2-) breast cancer (BC) with recurrence score (RS) < 25: SWOG S1007 (RxPonder)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Internal medicine; Oncology; Anthracycline; Breast cancer; Taxane; Randomized controlled trial; Gynecology; Proportional hazards model; Clinical endpoint; Sentinel lymph node; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001358079,0.0005432764,0.001392825,0.0001310995,0.0002206183,0.00006781502,0.0002905177,0.0001610442,0.0001734531],"category_scores_gemma":[0.0003782418,0.0003955925,0.0001804577,0.0005357054,0.001426004,0.00004156287,0.0001948173,0.0006694152,0.000002014982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004115125,"about_ca_system_score_gemma":0.00143767,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02156854,"about_ca_topic_score_gemma":0.01306194,"domain_scores_codex":[0.9948548,0.00109591,0.0009354371,0.00143065,0.0009620785,0.0007210954],"domain_scores_gemma":[0.995897,0.001072317,0.0004973599,0.0006269905,0.001658002,0.0002483071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9500422,0.002067445,0.01028011,0.00003095603,0.001976346,0.00004929734,0.001551439,0.00002133334,0.00371589,0.000007992626,0.00121134,0.02904561],"study_design_scores_gemma":[0.8212497,0.003620733,0.1270684,0.001130767,0.00009812005,0.000008767319,0.0003644697,0.000005070426,0.04467005,0.00003940305,0.001202124,0.0005423111],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805946,0.006529773,0.000057626,0.001963431,0.0001297271,0.002609137,0.007886508,0.00001357494,0.0002156574],"genre_scores_gemma":[0.9473147,0.04962702,0.0003896483,0.0001401872,0.0002888071,0.000935774,0.001126855,0.00007615754,0.0001008442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1287925,"threshold_uncertainty_score":0.9998496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04148298831501875,"score_gpt":0.3874085147198776,"score_spread":0.3459255264048589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}