{"id":"W3129688332","doi":"10.1097/hs9.0000000000000540","title":"Hemophilia Gene Therapy: Approaching the First Licensed Product","year":2021,"lang":"en","type":"review","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Clinical trial; Medicine; Intensive care medicine; Gene; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082495,0.0006602662,0.001057806,0.001810209,0.0002701395,0.001515998,0.0007700256,0.001829711,0.00502886],"category_scores_gemma":[0.001014846,0.0002769589,0.0004691424,0.001221868,0.000609322,0.002652282,0.0006998042,0.003017546,0.003002777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007487126,"about_ca_system_score_gemma":0.00137276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008387024,"about_ca_topic_score_gemma":0.001323046,"domain_scores_codex":[0.9997122,0.00005820989,0.00003430308,0.00004132257,0.0001308056,0.00002304817],"domain_scores_gemma":[0.999585,0.0002371247,0.00004609485,0.00001084276,0.00008853027,0.00003244768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008470543,0.0000689865,0.00009515307,0.01810175,0.00004541809,0.0003154666,0.0001236486,0.0003643189,0.004325795,0.01521509,0.04918533,0.9120743],"study_design_scores_gemma":[0.00001055661,0.00007888157,0.0001608588,0.003101019,0.00003332696,0.0008001305,0.00004836833,0.00006507534,0.0004685226,0.002291108,0.9929329,0.000009231741],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001237909,0.9967955,0.000226329,0.0006459289,0.0003001095,0.000005561279,0.00001733473,0.000009516717,0.001875943],"genre_scores_gemma":[0.0006113619,0.9976594,0.0002710125,0.0004171337,0.0001822678,0.000007220557,0.00002113035,0.000002801147,0.0008276078],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00502886,"threshold_uncertainty_score":0.01682323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062999990702083,"score_gpt":0.3599660407400558,"score_spread":0.2536660416698476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}