{"id":"W3129688332","doi":"10.1097/hs9.0000000000000540","title":"Hemophilia Gene Therapy: Approaching the First Licensed Product","year":2021,"lang":"en","type":"review","venue":"HemaSphere","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Genetic enhancement; Clinical trial; Medicine; Intensive care medicine; Gene; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009472823,0.0007643558,0.002571307,0.00008671641,0.0003304704,0.0001211213,0.0005749675,0.0003990018,0.01035845],"category_scores_gemma":[0.0001942861,0.0004443974,0.001315646,0.001013684,0.0001791452,0.00005059218,0.0002571624,0.001872211,0.0003504827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003055897,"about_ca_system_score_gemma":0.001099564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004752467,"about_ca_topic_score_gemma":0.00001993599,"domain_scores_codex":[0.9960365,0.000398776,0.0007386049,0.001122821,0.0009452215,0.0007581087],"domain_scores_gemma":[0.9964345,0.0003662026,0.0002726293,0.00250444,0.0001992978,0.0002229668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003952143,0.0002115728,0.000007356583,0.0115737,0.0008436888,0.0002358293,0.0002403328,5.185724e-7,0.00004768317,0.00006742776,0.01001799,0.9767144],"study_design_scores_gemma":[0.0006228209,0.00009974595,0.000004135245,0.007547821,0.0004699755,0.00112416,0.00006388997,0.000006619191,0.0001370675,0.000005698907,0.9895067,0.0004113487],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003363579,0.9796646,0.00001099208,0.001133961,0.0003335927,0.003761744,0.00001590215,0.0001407485,0.01490486],"genre_scores_gemma":[0.000005033183,0.9420991,0.0004634087,0.0004331356,0.002365611,0.0005421371,0.0002310747,0.000280296,0.05358023],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9794887,"threshold_uncertainty_score":0.9998008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1062999990702083,"score_gpt":0.3599660407400558,"score_spread":0.2536660416698476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}