{"id":"W3129727715","doi":"10.1016/j.devcel.2021.01.014","title":"Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring","year":2021,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; University of British Columbia; McGill University","funders":"Canadian Institutes of Health Research","keywords":"H3K4me3; Biology; Sperm; Epigenetics; Offspring; Embryo; Histone H3; Genetics; Histone; Enhancer; Embryogenesis; Phenotype; Andrology; Gene expression; Regulation of gene expression; Gene; Cell biology; Promoter; Pregnancy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001336101,0.0002316654,0.0002992811,0.0005993128,0.0002189067,0.0002809094,0.0003163329,0.0003978095,0.003057006],"category_scores_gemma":[0.0002370829,0.0003504909,0.0002724807,0.0002597495,0.0003203215,0.0001739996,0.0004549792,0.0009768337,0.0003906495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002862296,"about_ca_system_score_gemma":0.0002165135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00083267,"about_ca_topic_score_gemma":0.001721125,"domain_scores_codex":[0.9998336,0.00002503202,0.00001378983,0.00004472709,0.00004736717,0.0000354939],"domain_scores_gemma":[0.9996258,0.0000759367,0.0001305059,0.00005350728,0.00002956613,0.00008463704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002372048,0.00001700817,0.001677357,0.00001394036,0.00001380038,0.0002515855,0.00002260492,0.00002279155,0.9965715,0.0001106478,0.00003409151,0.001027469],"study_design_scores_gemma":[0.000039943,0.0002481041,0.1584508,0.00001279511,0.00006260451,0.001850584,0.000130248,0.0005212912,0.8369329,0.0001968795,0.001536916,0.0000170326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970658,0.0003881948,0.001233984,0.00008541923,0.00002697638,0.000005819325,0.0003498244,0.00006324422,0.0007806293],"genre_scores_gemma":[0.9913797,0.0003800549,0.0008056689,0.00005613134,0.00001116912,0.00001201217,0.0004577889,0.00006051669,0.006836847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003057006,"threshold_uncertainty_score":0.01022667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01292409185821013,"score_gpt":0.2407961036769917,"score_spread":0.2278720118187815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}