{"id":"W3129754483","doi":"10.1158/1538-7445.sabcs20-pd1-02","title":"Abstract PD1-02: A phase I/Ib study evaluating GDC-0077 + palbociclib (palbo) + fulvestrant in patients (pts) with <i>PIK3CA</i>-mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Palbociclib; Phases of clinical research; Breast cancer; Oncology; Progressive disease; Cancer; Pharmacology; Chemotherapy; Gastroenterology; Metastatic breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025975,0.001409966,0.001320211,0.0005275491,0.0003390964,0.001144913,0.001081781,0.0008671887,0.005660499],"category_scores_gemma":[0.0005403275,0.0005329707,0.0009402143,0.0004558818,0.0008815398,0.0006500584,0.0003268079,0.002681396,0.001417288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284766,"about_ca_system_score_gemma":0.001957348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001639499,"about_ca_topic_score_gemma":0.003574568,"domain_scores_codex":[0.9997035,0.0001214291,0.00001335782,0.00005659145,0.00003647524,0.00006862445],"domain_scores_gemma":[0.999651,0.00003756291,0.00005002858,0.00002411183,0.00002522524,0.0002120297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.713861,0.08004984,0.00654586,0.001077488,0.0009950133,0.0002819339,0.0002077756,0.003934487,0.06528044,0.0004575719,0.006755014,0.1205535],"study_design_scores_gemma":[0.5151356,0.4612432,0.009436512,0.00004914013,0.0005009288,0.0003151672,0.00007553214,0.001545126,0.006827311,0.0002567261,0.004581043,0.00003366743],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839569,0.001763626,0.0007615848,0.0004142223,0.00009627568,0.004647193,0.003310112,0.0001957606,0.004854356],"genre_scores_gemma":[0.9819514,0.001757086,0.001714818,0.0008816549,0.0001150821,0.003054825,0.005340199,0.00004987622,0.005135071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005660499,"threshold_uncertainty_score":0.01893628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07982276108933845,"score_gpt":0.4456599860075646,"score_spread":0.3658372249182262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}