{"id":"W3129754483","doi":"10.1158/1538-7445.sabcs20-pd1-02","title":"Abstract PD1-02: A phase I/Ib study evaluating GDC-0077 + palbociclib (palbo) + fulvestrant in patients (pts) with <i>PIK3CA</i>-mutant (mut), hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Fulvestrant; Internal medicine; Palbociclib; Phases of clinical research; Breast cancer; Oncology; Progressive disease; Cancer; Pharmacology; Chemotherapy; Gastroenterology; Metastatic breast cancer; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002206581,0.0008488314,0.001469899,0.000561138,0.0005006903,0.0001861892,0.0005288016,0.000179664,0.00315458],"category_scores_gemma":[0.0004150563,0.0007094271,0.0002006131,0.002975816,0.0007709765,0.000665637,0.0002712724,0.002290051,0.00008255229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003248918,"about_ca_system_score_gemma":0.00359515,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008438341,"about_ca_topic_score_gemma":0.005087265,"domain_scores_codex":[0.9899452,0.001232504,0.001207918,0.001898236,0.003680019,0.002036088],"domain_scores_gemma":[0.9936707,0.0008209297,0.0004310508,0.001134926,0.003170778,0.0007715838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0607807,0.023956,0.1345821,0.001311112,0.004520023,0.00331577,0.03168214,0.001274355,0.3155417,0.00004204838,0.0009449061,0.4220491],"study_design_scores_gemma":[0.1011842,0.01384529,0.7835203,0.005657682,0.0007661844,0.0001840171,0.025844,0.000235703,0.06552742,0.0002936759,0.0009638802,0.001977637],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878162,0.003423708,0.00005959146,0.002173825,0.0002356359,0.004503892,0.001227416,0.0001092111,0.0004505035],"genre_scores_gemma":[0.9936608,0.0008943562,0.0009666912,0.0003293225,0.0004303315,0.002775509,0.0001655037,0.0002571883,0.0005203107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6489382,"threshold_uncertainty_score":0.9995357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07982276108933845,"score_gpt":0.4456599860075646,"score_spread":0.3658372249182262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}