{"id":"W3129799050","doi":"10.1111/gtc.12842","title":"Human SIRT2 and SIRT3 deacetylases function in DNA homologous recombinational repair","year":2021,"lang":"en","type":"article","venue":"Genes to Cells","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science","keywords":"SIRT2; Biology; RAD51; SIRT3; DNA repair; Sirtuin; Cell biology; Homologous recombination; RAD52; Ku80; Non-homologous end joining; Genetics; DNA; Acetylation; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003046252,0.0005046516,0.0003970492,0.0003259028,0.0002744552,0.0005232218,0.0002731021,0.0004105146,0.002578338],"category_scores_gemma":[0.0002108545,0.0001533059,0.0006860796,0.0003825701,0.000245847,0.0002216232,0.0002551241,0.0003823741,0.001131483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004811993,"about_ca_system_score_gemma":0.0002739107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011307,"about_ca_topic_score_gemma":0.001686679,"domain_scores_codex":[0.9997963,0.00004332957,0.00001474261,0.00005459352,0.00004881868,0.00004209602],"domain_scores_gemma":[0.9998938,0.000009535715,0.00002945752,0.00001964335,0.00002269453,0.00002498974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008974209,0.00007819248,0.00749161,0.0004571956,0.0002107196,0.000316432,0.00009629974,0.0006284572,0.9502002,0.001800002,0.00156539,0.03625798],"study_design_scores_gemma":[0.0001492816,0.0005575191,0.0710957,0.00004687759,0.0002901939,0.001943043,0.0001278045,0.002729931,0.8343148,0.001137234,0.08755639,0.00005120463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8387013,0.0955087,0.03529845,0.0008606025,0.0005888126,0.0001614817,0.005015144,0.001121353,0.02274415],"genre_scores_gemma":[0.9799587,0.006783758,0.00388615,0.0001698074,0.0000508858,0.0000353353,0.002672249,0.00004437031,0.006398709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578338,"threshold_uncertainty_score":0.008625448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485110386637325,"score_gpt":0.266621505755585,"score_spread":0.2517704018892118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}