{"id":"W3129818993","doi":"10.1139/cjpp-2020-0588","title":"Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Liaoning Province","keywords":"Cyclopamine; PI3K/AKT/mTOR pathway; Cancer research; Apoptosis; Sonic hedgehog; Downregulation and upregulation; Smoothened; Colorectal cancer; LY294002; Protein kinase B; Cancer cell; Hedgehog signaling pathway; Cell growth; Chemistry; Cancer; Signal transduction; Biology; Internal medicine; Medicine; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007789532,0.0004519812,0.0002390624,0.0004176676,0.0001180643,0.0001581181,0.0001165501,0.000218478,0.0005503081],"category_scores_gemma":[0.00006405225,0.0001105809,0.0004225296,0.0002113724,0.0001372386,0.0001616116,0.0001447657,0.000337335,0.0001458101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129052,"about_ca_system_score_gemma":0.0002127597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007722658,"about_ca_topic_score_gemma":0.00166124,"domain_scores_codex":[0.9999223,0.00001505338,0.000008358403,0.000009823588,0.00001962825,0.00002482877],"domain_scores_gemma":[0.9999737,0.000003615516,0.000007683952,0.000003598794,0.000004441333,0.000007095436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004572301,0.0000735122,0.0003619526,0.0001370508,0.00003026051,0.0001004593,0.000015288,0.0000913292,0.9941764,0.00005447662,0.00006125667,0.004440832],"study_design_scores_gemma":[0.00006406445,0.001220575,0.01584453,0.00001551046,0.0001053917,0.0004144867,0.00003103792,0.0006998634,0.9783583,0.00007710519,0.003160331,0.000008892396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884549,0.008472398,0.001166693,0.0001878824,0.00004409166,0.00002907726,0.000183686,0.00008769986,0.001373583],"genre_scores_gemma":[0.9935805,0.003608097,0.0007876296,0.0001445939,0.00001423304,0.00003325717,0.0003351943,0.000008506711,0.001488049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007722658,"threshold_uncertainty_score":0.001840949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135993388767757,"score_gpt":0.2545114873278062,"score_spread":0.2409121484510305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}