{"id":"W3129828049","doi":"10.3390/curroncol28010090","title":"Primary Signet Ring Cell/Histiocytoid Carcinoma of the Eyelid: Somatic Mutations in CDH1 and Other Clinically Actionable Mutations Imply Early Use of Targeted Agents","year":2021,"lang":"en","type":"article","venue":"Current Oncology","topic":"Cancer and Skin Lesions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Taipei Veterans General Hospital","keywords":"Signet ring cell carcinoma; Signet ring cell; CDH1; Pathology; Medicine; Basal cell carcinoma; Eyelid; Carcinoma; Cancer; Cadherin; Biology; Adenocarcinoma; Internal medicine; Cell; Basal cell; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000141899,0.00009035366,0.0003328864,0.0001032783,0.00006449427,0.000006117609,0.00005961325,0.0000858787,0.0002072849],"category_scores_gemma":[0.0002808701,0.00007605124,0.0000902174,0.0002602891,0.0001661166,0.00005831817,0.00006864037,0.0002292281,0.000003858068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001643641,"about_ca_system_score_gemma":0.0007545053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001585752,"about_ca_topic_score_gemma":0.0001281032,"domain_scores_codex":[0.9987921,0.0001726976,0.00054809,0.00018682,0.0001499554,0.0001503368],"domain_scores_gemma":[0.9988617,0.0004855943,0.0002096509,0.0002225731,0.0001509091,0.00006958508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000120104,0.001321488,0.9544747,0.0004520586,0.00005085217,0.00002934021,0.003430402,0.0002460043,0.03262269,0.0001364897,0.0007473477,0.006368479],"study_design_scores_gemma":[0.002127886,0.0002220933,0.9881543,0.0001332738,0.0001550179,0.00003767669,0.0003837605,0.0004894034,0.002598056,0.0002104438,0.005413405,0.00007470714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971461,0.000594928,0.0002255524,0.0002780838,0.0004215471,0.0003374572,0.00008016976,0.000008756215,0.0009074482],"genre_scores_gemma":[0.9985708,0.00007195555,0.0008408776,0.0001420092,0.00004635287,0.00003965601,0.00004747544,0.0000125926,0.0002282596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03367953,"threshold_uncertainty_score":0.310128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.117808442881494,"score_gpt":0.3962096884704062,"score_spread":0.2784012455889122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}