{"id":"W3129851337","doi":"10.1158/1538-7445.sabcs20-ot-13-02","title":"Abstract OT-13-02: Bracelet-1 (pre0113): A study to assess overall response rate by inducing an inflammatory phenotype in metastatic breast cancer with the oncolytic reovirus pelareorep in combination with anti-PD-L1 avelumab and paclitaxel","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Breast cancer; Metastatic breast cancer; Medicine; Immune system; Oncolytic virus; CD8; Biomarker; Oncology; Internal medicine; Cancer; Immune checkpoint; Paclitaxel; Immunology; Cancer research; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001620792,0.001194787,0.001795452,0.0005466082,0.0002848165,0.0008029653,0.001205263,0.0009997645,0.005478563],"category_scores_gemma":[0.0006609875,0.000566038,0.001170742,0.0005730486,0.0009273351,0.0006788468,0.0002701781,0.003088338,0.001144353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001011896,"about_ca_system_score_gemma":0.00142913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001177179,"about_ca_topic_score_gemma":0.002027306,"domain_scores_codex":[0.999405,0.0002498913,0.00003142785,0.0001053757,0.00007215784,0.0001360029],"domain_scores_gemma":[0.999495,0.00009402898,0.00009790745,0.00006063202,0.00002527789,0.0002271283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5897951,0.1392653,0.003271223,0.0008163981,0.0008018652,0.0002345882,0.000137496,0.0009095478,0.1543419,0.0002746851,0.002373181,0.1077787],"study_design_scores_gemma":[0.1112468,0.8661758,0.006525153,0.00002024835,0.0003092115,0.0002119051,0.00003331312,0.0004759099,0.01320986,0.00005403919,0.001716681,0.00002120162],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960025,0.001179417,0.0003422281,0.0001578243,0.00008706379,0.0006801873,0.0005871484,0.00007541011,0.000888303],"genre_scores_gemma":[0.9895627,0.001468188,0.0009470911,0.0003698376,0.0001469898,0.001206558,0.00187663,0.00003823918,0.004383835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005478563,"threshold_uncertainty_score":0.01832759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04729007422189422,"score_gpt":0.3885531600493882,"score_spread":0.341263085827494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}