{"id":"W3129853752","doi":"10.1158/1538-7445.sabcs20-pd12-06","title":"Abstract PD12-06: Treatment-related amenorrhea with T-DM1 plus pertuzumab (KP) is lower than with docetaxel/carboplatin/trastuzumab/pertuzumab (TCHP) in the phase III neoadjuvant KRISTINE trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University Health Centre","funders":"","keywords":"Pertuzumab; Medicine; Trastuzumab; Docetaxel; Internal medicine; Oncology; Breast cancer; Clinical endpoint; Gynecology; Neoadjuvant therapy; Amenorrhea; Cancer; Clinical trial; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248043,0.0005047368,0.001392262,0.0001697222,0.0002229552,0.001044965,0.0005129444,0.0006797409,0.00618905],"category_scores_gemma":[0.001136015,0.000269546,0.001132078,0.0002598124,0.0004220274,0.0005297609,0.0002676752,0.002335103,0.0006332356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005151448,"about_ca_system_score_gemma":0.0007106608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006145191,"about_ca_topic_score_gemma":0.002185025,"domain_scores_codex":[0.9995028,0.0002707873,0.00003805824,0.0000775602,0.00005071062,0.0000601564],"domain_scores_gemma":[0.999339,0.0001657754,0.0001748989,0.00004982359,0.00004151008,0.0002289803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9118843,0.003905961,0.003343564,0.0009127546,0.001630922,0.00004135465,0.00007839828,0.0005657945,0.005878553,0.0001037354,0.003063086,0.06859166],"study_design_scores_gemma":[0.7106349,0.2418785,0.03296322,0.000182927,0.002856658,0.0003966624,0.0001022578,0.001212409,0.003335615,0.0002876581,0.006106821,0.00004230811],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892349,0.005652749,0.0002194428,0.0006101078,0.0001337717,0.000395761,0.00126938,0.0001004924,0.002383429],"genre_scores_gemma":[0.994758,0.001372244,0.0003459601,0.0003968651,0.00009156432,0.0002533656,0.001102585,0.00001833943,0.001661152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00618905,"threshold_uncertainty_score":0.02070445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04710462911135783,"score_gpt":0.3732314727476038,"score_spread":0.326126843636246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}