{"id":"W3129911683","doi":"10.1093/noajnl/vdab002","title":"Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medulloblastoma; Cancer research; Peptidomimetic; Suppressor; Phenotype; Thrombospondin 1; Biology; Apoptosis; In vitro; Thrombospondin; Psychological repression; Overall survival; Medicine; Oncology; Cancer; Gene; Genetics; Gene expression; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001395244,0.0002329744,0.000332727,0.00003249993,0.0002060175,0.00002438787,0.0002090849,0.0003141383,0.00002369645],"category_scores_gemma":[0.0002933353,0.0002269603,0.000205037,0.0001579388,0.0001523368,0.000009391658,0.0001022598,0.0001160081,0.000004154019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005153938,"about_ca_system_score_gemma":0.0002726095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.880918e-7,"about_ca_topic_score_gemma":0.00008952981,"domain_scores_codex":[0.9985211,0.00008493778,0.0002873278,0.0005630167,0.0001325306,0.0004110334],"domain_scores_gemma":[0.9988859,0.0001492244,0.0002588136,0.0003071029,0.0003229846,0.00007599458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001589017,0.0002923277,0.00368967,0.00002724548,0.000158097,0.00001230292,0.00005707383,0.000118149,0.987715,0.0001395677,0.001138195,0.006493467],"study_design_scores_gemma":[0.001172814,0.0006134216,0.001760988,0.00001904942,0.00009475072,0.00003870292,0.0002963139,0.00008258148,0.5409148,0.0001309181,0.4546369,0.0002387286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768534,0.01226479,0.006407471,0.001523884,0.001496921,0.0004319394,0.0001830908,0.00004902858,0.0007895073],"genre_scores_gemma":[0.9807075,0.003169322,0.008857793,0.005615204,0.0006634877,0.00006773066,0.000196465,0.00008637599,0.0006361209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4534987,"threshold_uncertainty_score":0.9255173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290570082902973,"score_gpt":0.3233107360521877,"score_spread":0.2942537277618905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}