{"id":"W3129911683","doi":"10.1093/noajnl/vdab002","title":"Thrombospondin-1 mimetics are promising novel therapeutics for MYC-associated medulloblastoma","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Medulloblastoma; Cancer research; Peptidomimetic; Suppressor; Phenotype; Thrombospondin 1; Biology; Apoptosis; In vitro; Thrombospondin; Psychological repression; Overall survival; Medicine; Oncology; Cancer; Gene; Genetics; Gene expression; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005788346,0.0001724217,0.0001190788,0.0001271836,0.00005605348,0.0001215785,0.000107039,0.0001212887,0.0008594532],"category_scores_gemma":[0.00004009045,0.0000496887,0.0001060984,0.00007229287,0.00008161632,0.0000986508,0.00009195529,0.0002840071,0.0001338516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001757628,"about_ca_system_score_gemma":0.000106943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002111623,"about_ca_topic_score_gemma":0.0006479742,"domain_scores_codex":[0.9999839,0.000003209486,0.000001261074,0.000002470024,0.000004288869,0.000004757303],"domain_scores_gemma":[0.9999827,0.00000257411,0.000006376807,5.970592e-7,0.000002010054,0.000005816008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007638099,0.0002059707,0.0006245452,0.0002314153,0.00002410632,0.0003936315,0.0000220502,0.0009433611,0.9515906,0.0007589599,0.0005384535,0.04390303],"study_design_scores_gemma":[0.001123513,0.01318963,0.01803168,0.00008259113,0.0001474575,0.003396571,0.00008800134,0.004871945,0.9046966,0.001067569,0.05327754,0.00002690788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728832,0.01908308,0.003413731,0.0003850092,0.00009045861,0.00009933779,0.0003732591,0.000108517,0.003563365],"genre_scores_gemma":[0.9825032,0.01196584,0.002667374,0.0001068339,0.00003134499,0.00004849884,0.0004206177,0.000008138027,0.002248222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008594532,"threshold_uncertainty_score":0.00287509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0290570082902973,"score_gpt":0.3233107360521877,"score_spread":0.2942537277618905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}