{"id":"W3129923342","doi":"10.1158/1538-7445.sabcs20-pd14-07","title":"Abstract PD14-07: Association between biomarkers and response to pembrolizumab in patients with metastatic triple-negative breast cancer (mTNBC): Exploratory analysis from KEYNOTE-086","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Internal medicine; Cohort; Triple-negative breast cancer; Breast cancer; Biomarker; Cancer; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006569283,0.0003630496,0.0004400422,0.0003857996,0.0002719837,0.0005712351,0.0004711757,0.0003988621,0.001947889],"category_scores_gemma":[0.0009453669,0.0002441062,0.0005475469,0.0004263598,0.0002040436,0.0003856338,0.0005316039,0.0006382202,0.0003966884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004351929,"about_ca_system_score_gemma":0.0003894446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006953537,"about_ca_topic_score_gemma":0.001188125,"domain_scores_codex":[0.999658,0.00009247669,0.00002891352,0.0001142811,0.00006543049,0.00004091569],"domain_scores_gemma":[0.9993886,0.00009986347,0.0002081518,0.00007309172,0.00006781005,0.0001625903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02393401,0.0007713479,0.9540345,0.0001093406,0.0008790812,0.0002033574,0.00008679625,0.0005223633,0.008446962,0.00006380386,0.001296369,0.009652025],"study_design_scores_gemma":[0.001019136,0.003714336,0.9904894,0.00001413008,0.0003438084,0.0005543547,0.0001021011,0.001113496,0.001314714,0.00007115724,0.001247832,0.00001560492],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980049,0.000164946,0.00008200825,0.00003085677,0.00000332483,0.00003972314,0.00142832,0.000005608342,0.0002403658],"genre_scores_gemma":[0.9970943,0.00004317312,0.0002082048,0.00004700049,0.00001275504,0.00004581734,0.002307564,0.000002907242,0.0002382827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001947889,"threshold_uncertainty_score":0.006516278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04501016533167566,"score_gpt":0.3672172241175309,"score_spread":0.3222070587858552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}