{"id":"W3129961151","doi":"10.1002/brb3.2063","title":"Pyroptosis executive protein GSDMD as a biomarker for diagnosis and identification of Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"Brain and Behavior","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cerebrospinal fluid; Medicine; Biomarker; Dementia; Montreal Cognitive Assessment; Lumbar puncture; Clinical Dementia Rating; Vascular dementia; Internal medicine; Alzheimer's disease; Gastroenterology; Disease; Pathology; Oncology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005446902,0.0004568018,0.0003332807,0.001312336,0.0002332001,0.000548296,0.0001813731,0.000329934,0.0006015871],"category_scores_gemma":[0.0005643594,0.0001401363,0.0002353489,0.000582647,0.0002706393,0.0003136589,0.0003850761,0.0003256671,0.0001431461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839981,"about_ca_system_score_gemma":0.0001371178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003778113,"about_ca_topic_score_gemma":0.0003951864,"domain_scores_codex":[0.999761,0.00006814201,0.00003633606,0.00005796777,0.0000504243,0.00002611409],"domain_scores_gemma":[0.9997637,0.00003878466,0.000089653,0.00001104054,0.00005246402,0.0000444205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001524017,0.0002600194,0.9267488,0.0002563686,0.0001892394,0.001032591,0.0001814146,0.0002158432,0.03778304,0.00009572177,0.0004317122,0.03128126],"study_design_scores_gemma":[0.00007751882,0.001351666,0.9750182,0.00007071583,0.0001951946,0.005720619,0.0003819846,0.002371281,0.01219614,0.0004839815,0.002108403,0.00002431889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910671,0.006675541,0.0009974802,0.00009781148,0.00004914116,0.00002940266,0.0001902067,0.00001984154,0.0008734008],"genre_scores_gemma":[0.9967039,0.001077634,0.001576741,0.00006336558,0.00005212912,0.00002002511,0.0001637439,0.000001915936,0.0003404411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312336,"threshold_uncertainty_score":0.002880692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184319335903262,"score_gpt":0.2902542534333185,"score_spread":0.2718223198429923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}