{"id":"W3130023215","doi":"10.1200/po.20.00419","title":"Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC","year":2021,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Medicine; Cohort; Oncology; Osimertinib; Internal medicine; KRAS; T790M; Lung cancer; Digital polymerase chain reaction; Cancer; Biology; Polymerase chain reaction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001041118,0.00028317,0.0004932323,0.0005562675,0.000167193,0.0004929451,0.0002451798,0.0003924705,0.0008960684],"category_scores_gemma":[0.003221821,0.0001476531,0.0001983653,0.0004390506,0.0002063459,0.0003723937,0.0002652857,0.0005888792,0.0002116106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004147411,"about_ca_system_score_gemma":0.0001947023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005375105,"about_ca_topic_score_gemma":0.0007715403,"domain_scores_codex":[0.9990764,0.0002384446,0.0001005761,0.0002105573,0.0003151383,0.0000588988],"domain_scores_gemma":[0.9970176,0.001024828,0.001376183,0.0001420192,0.0002650695,0.0001742548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004929155,0.0002729122,0.7745688,0.0002247226,0.000172806,0.0002515634,0.0002065319,0.001779044,0.1472286,0.0001123024,0.0005890208,0.06966459],"study_design_scores_gemma":[0.00003740964,0.002634106,0.9597936,0.00001958545,0.00007329756,0.0009610991,0.00007744793,0.002446872,0.03236492,0.0001004167,0.001475758,0.0000155834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920759,0.002577037,0.002711251,0.00009429717,0.0000220645,0.0000727294,0.0007418851,0.0001156623,0.001589132],"genre_scores_gemma":[0.9981791,0.0001952478,0.000806057,0.00005902103,0.00001684767,0.0000342239,0.0003605269,0.0000113341,0.0003376247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001041118,"threshold_uncertainty_score":0.005505979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130966784847513,"score_gpt":0.3105240036687769,"score_spread":0.2992143358203017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}