{"id":"W3130023215","doi":"10.1200/po.20.00419","title":"Plasma ctDNA Response Is an Early Marker of Treatment Effect in Advanced NSCLC","year":2021,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; U.S. Department of Defense","keywords":"Medicine; Cohort; Oncology; Osimertinib; Internal medicine; KRAS; T790M; Lung cancer; Digital polymerase chain reaction; Cancer; Biology; Polymerase chain reaction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003484594,0.0001583469,0.0003239602,0.00007010412,0.0000275009,0.00001007812,0.0001294903,0.0002627332,0.00009945842],"category_scores_gemma":[0.0004795785,0.0001407583,0.0001096959,0.0001125158,0.00004937246,0.000004249562,0.0001212884,0.00006980278,0.00001349699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001714238,"about_ca_system_score_gemma":0.0004789183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005525259,"about_ca_topic_score_gemma":0.0004029481,"domain_scores_codex":[0.99857,0.0003944524,0.0003067636,0.0004323919,0.00008203916,0.0002143563],"domain_scores_gemma":[0.9987733,0.0004421292,0.0001029224,0.0004925493,0.0000956193,0.00009351206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01102673,0.0003582447,0.01149019,0.000006361437,0.0000401256,0.00006995962,0.000234608,0.000188646,0.7589783,0.00001286623,0.000822454,0.2167715],"study_design_scores_gemma":[0.005381912,0.01451071,0.06870525,0.00002851734,0.00002483913,0.00002399385,0.00007669349,0.0001296107,0.7487341,0.000109086,0.1620612,0.0002140898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971312,0.0006549025,0.00006701033,0.0002206705,0.0003067572,0.000239937,0.00006019458,0.00000458148,0.001314781],"genre_scores_gemma":[0.996203,0.0008535552,0.001413882,0.0002809674,0.00007270588,0.00005905836,0.00006153552,0.00002114521,0.001034116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2165574,"threshold_uncertainty_score":0.5739959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130966784847513,"score_gpt":0.3105240036687769,"score_spread":0.2992143358203017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}