{"id":"W3130061971","doi":"10.1002/hbm.25354","title":"Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the<scp>ENIGMA</scp>working groups on<scp>CNVs</scp>","year":2021,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Institute for Clinical Evaluative Sciences; University of British Columbia; Hospital for Sick Children; SickKids Foundation; University Health Network; Toronto General Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"FP7 Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; South London and Maudsley NHS Foundation Trust; National Institute on Drug Abuse; Faculty of Medicine and Health, University of Sydney; King's College London; European Regional Development Fund; National Institute of Mental Health; Helse Sør-Øst RHF; National Health and Medical Research Council; Epilepsy Society; Medical Research Council; Amsterdam Neuroscience; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Instituto de Investigación Marqués de Valdecilla; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Horizon 2020 Framework Programme; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; Canada First Research Excellence Fund; Fondation Leenaards; Norges Forskningsråd; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen; Centro de Investigación Biomédica en Red de Salud Mental; Instituto de Salud Carlos III; Helse Midt-Norge; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation Brain Canada; Ministerio de Ciencia e Innovación; European Commission; National Institute on Aging; National Institute for Health and Care Research; Norwegian Institute of Public Health; Avera Institute for Human Genetics; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Fundación Alicia Koplowitz; Michael Smith Health Research BC; Norges Teknisk-Naturvitenskapelige Universitet; Heart and Stroke Foundation of Canada; Fondation Roger de Spoelberch; Compute Canada; National Science Foundation","keywords":"Copy-number variation; Psychology; Scale (ratio); Neuroscience; Psychiatry; Computational biology; Genetics; Biology; Gene; Genome; Cartography; Geography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004826378,0.0006178555,0.001245073,0.0001153904,0.00104297,0.0001265079,0.0004092823,0.0005242497,0.00001005542],"category_scores_gemma":[0.001587889,0.0004968441,0.000528513,0.0002743476,0.0001093951,0.000008253809,0.0002859638,0.0004425784,0.000004230981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000537618,"about_ca_system_score_gemma":0.0001315121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002017328,"about_ca_topic_score_gemma":0.00009692018,"domain_scores_codex":[0.9970484,0.0006488702,0.0007370968,0.0008517061,0.0002278638,0.0004860601],"domain_scores_gemma":[0.9942052,0.004088828,0.0008378341,0.0006446258,0.0001422242,0.00008127149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004128581,0.002681654,0.01798032,0.09242338,0.04389466,0.00006824257,0.07555667,0.0005047932,0.01224263,0.1119417,0.5147216,0.127943],"study_design_scores_gemma":[0.001093237,0.0002066381,0.001719273,0.003994592,0.001159545,0.00001399271,0.003133606,0.00001415676,0.0001903394,0.003338774,0.9848961,0.0002397897],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08415639,0.9100112,0.001547682,0.00008477358,0.0006437346,0.001633308,0.001538681,0.00002982285,0.0003543828],"genre_scores_gemma":[0.03706798,0.9503178,0.001952324,0.0009929675,0.003233975,0.0006235518,0.003444543,0.0002040782,0.002162777],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4701744,"threshold_uncertainty_score":0.9997483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920163876968048,"score_gpt":0.2853755521020914,"score_spread":0.2661739133324109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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