{"id":"W3130061971","doi":"10.1002/hbm.25354","title":"Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the<scp>ENIGMA</scp>working groups on<scp>CNVs</scp>","year":2021,"lang":"en","type":"review","venue":"Human Brain Mapping","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"Holland Bloorview Kids Rehabilitation Hospital; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; Institute for Clinical Evaluative Sciences; University of British Columbia; Hospital for Sick Children; SickKids Foundation; University Health Network; Toronto General Hospital; University of Toronto; Centre for Addiction and Mental Health","funders":"FP7 Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; South London and Maudsley NHS Foundation Trust; National Institute on Drug Abuse; Faculty of Medicine and Health, University of Sydney; King's College London; European Regional Development Fund; National Institute of Mental Health; Helse Sør-Øst RHF; National Health and Medical Research Council; Epilepsy Society; Medical Research Council; Amsterdam Neuroscience; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Instituto de Investigación Marqués de Valdecilla; Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet; Horizon 2020 Framework Programme; National Institutes of Health; Agencia Nacional de Investigación y Desarrollo; Canada First Research Excellence Fund; Fondation Leenaards; Norges Forskningsråd; National Center for Research Resources; National Alliance for Research on Schizophrenia and Depression; ZonMw; Koninklijke Nederlandse Akademie van Wetenschappen; Centro de Investigación Biomédica en Red de Salud Mental; Instituto de Salud Carlos III; Helse Midt-Norge; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Fondation Brain Canada; Ministerio de Ciencia e Innovación; European Commission; National Institute on Aging; National Institute for Health and Care Research; Norwegian Institute of Public Health; Avera Institute for Human Genetics; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; Fundación Alicia Koplowitz; Michael Smith Health Research BC; Norges Teknisk-Naturvitenskapelige Universitet; Heart and Stroke Foundation of Canada; Fondation Roger de Spoelberch; Compute Canada; National Science Foundation","keywords":"Copy-number variation; Psychology; Scale (ratio); Neuroscience; Psychiatry; Computational biology; Genetics; Biology; Gene; Genome; Cartography; Geography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005586377,0.0008788221,0.001588987,0.002318697,0.0004962447,0.001379531,0.0008789765,0.0007921167,0.002236666],"category_scores_gemma":[0.01422857,0.0005096287,0.004742293,0.003522069,0.00052066,0.0005908929,0.001373192,0.0009262983,0.0002718455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005015979,"about_ca_system_score_gemma":0.000761069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007507436,"about_ca_topic_score_gemma":0.01252786,"domain_scores_codex":[0.9969977,0.0009101118,0.0006192432,0.0009591429,0.0003913861,0.0001224273],"domain_scores_gemma":[0.9902136,0.006955049,0.001084378,0.0008154375,0.000759161,0.0001724341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003133596,0.00006307477,0.6529413,0.01878249,0.1657894,0.001813661,0.001146445,0.001485651,0.007806173,0.001276836,0.008631537,0.13713],"study_design_scores_gemma":[0.0002007965,0.000219846,0.8811876,0.00238241,0.09212667,0.001394408,0.0002309009,0.0004225087,0.001090664,0.001699741,0.01896333,0.00008125237],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4017262,0.5638458,0.008376756,0.002253137,0.000334177,0.0003434876,0.0194665,0.0001370709,0.003516866],"genre_scores_gemma":[0.831689,0.1421085,0.00881584,0.001844976,0.0004399604,0.0007042516,0.01325803,0.0001828181,0.0009565115],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007507436,"threshold_uncertainty_score":0.02954388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01920163876968048,"score_gpt":0.2853755521020914,"score_spread":0.2661739133324109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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