{"id":"W3130092810","doi":"10.1186/s13072-021-00386-8","title":"Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biology; X-inactivation; Gene; Genetics; X chromosome; Epigenetics; DNA methylation; CTCF; Y chromosome; Skewed X-inactivation; Chromosome; Gene expression; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001728396,0.0001913951,0.0003182805,0.00005076681,0.00007876417,0.00002865313,0.0002142599,0.0002102895,0.0004390066],"category_scores_gemma":[0.00023257,0.0001935366,0.0001441287,0.0001624081,0.0002214539,0.0000115147,0.000140532,0.00007355561,0.000007669737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000199247,"about_ca_system_score_gemma":0.0001148203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002681767,"about_ca_topic_score_gemma":0.00003421912,"domain_scores_codex":[0.9982358,0.0001323001,0.0007299341,0.0003644039,0.0003415284,0.0001959903],"domain_scores_gemma":[0.9985285,0.0001022577,0.0004038367,0.0004271352,0.0004647779,0.00007348287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001949067,0.0001899692,0.002735964,0.00007535068,0.00006064695,0.000004281992,0.0003403979,0.00009021573,0.9930252,0.0006474562,0.00005591481,0.002755047],"study_design_scores_gemma":[0.0005057048,0.0002378435,0.2285057,0.00005735379,0.00002305844,0.000003662971,0.0005233958,0.00007024056,0.7684419,0.0002645986,0.001205623,0.0001609641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933324,0.0008724159,0.0009636012,0.0000823929,0.0001870955,0.0001111667,0.0001085988,0.00001235912,0.004329966],"genre_scores_gemma":[0.9934532,0.0005989085,0.003405242,0.0000538881,0.0002271356,0.00001021691,0.0004136832,0.00002190866,0.001815786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2257697,"threshold_uncertainty_score":0.7892192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407279449128713,"score_gpt":0.2603389452449604,"score_spread":0.2462661507536733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}