{"id":"W3130092810","doi":"10.1186/s13072-021-00386-8","title":"Cross-species examination of X-chromosome inactivation highlights domains of escape from silencing","year":2021,"lang":"en","type":"article","venue":"Epigenetics & Chromatin","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Biology; X-inactivation; Gene; Genetics; X chromosome; Epigenetics; DNA methylation; CTCF; Y chromosome; Skewed X-inactivation; Chromosome; Gene expression; Enhancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004344216,0.0001496682,0.0001847125,0.0008520046,0.0002634239,0.0002738838,0.0002235843,0.0003018107,0.002094895],"category_scores_gemma":[0.0005235735,0.00009604808,0.0002008294,0.0005846418,0.000360337,0.0002351838,0.0005490761,0.0002279548,0.0002349758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001407496,"about_ca_system_score_gemma":0.0001001196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006574258,"about_ca_topic_score_gemma":0.001755167,"domain_scores_codex":[0.9997186,0.00003263354,0.00002153696,0.000143287,0.00004964039,0.00003420348],"domain_scores_gemma":[0.9993904,0.0001726762,0.0002391576,0.00006165526,0.00007928417,0.00005694191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002984706,0.00002681318,0.2083403,0.0003413218,0.000197392,0.0001733788,0.0004991887,0.0001386041,0.7816375,0.0001702632,0.0001069341,0.008069893],"study_design_scores_gemma":[0.000002235456,0.0001460498,0.971713,0.00002599244,0.00007377703,0.0006080223,0.0003171935,0.0003163184,0.02534842,0.0001479711,0.001295194,0.000005912204],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958931,0.001201671,0.001176201,0.00002115093,0.000004409942,0.000007287279,0.000527812,0.00002957569,0.001138724],"genre_scores_gemma":[0.9977053,0.0002221084,0.000954151,0.00005339949,0.000003164009,0.00001465131,0.0007051906,0.00001621236,0.0003257539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094895,"threshold_uncertainty_score":0.007008135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01407279449128713,"score_gpt":0.2603389452449604,"score_spread":0.2462661507536733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}