{"id":"W3130146550","doi":"10.1158/1538-7445.sabcs20-ps11-03","title":"Abstract PS11-03: Safety and efficacy of veliparib plus carboplatin/paclitaxel in patients with HER2-negative metastatic or locally advanced breast cancer: A subgroup analysis of germline <i>BRCA1</i> or <i>BRCA2</i> mutations from the phase 3 BROCADE3 trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Veliparib; Carboplatin; Internal medicine; Hazard ratio; Breast cancer; Metastatic breast cancer; Oncology; Neutropenia; Paclitaxel; Chemotherapy; Gastroenterology; Cancer; Confidence interval; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001219909,0.0008372802,0.001749718,0.0003376611,0.0002510501,0.0009474471,0.0004088813,0.0006059971,0.003128157],"category_scores_gemma":[0.001109653,0.0002506153,0.003604259,0.0005502137,0.0003463987,0.0004373523,0.0003437216,0.001187779,0.0004010438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006557357,"about_ca_system_score_gemma":0.001105143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009736096,"about_ca_topic_score_gemma":0.001934912,"domain_scores_codex":[0.9994351,0.0002737993,0.00006407606,0.0001023602,0.00005355072,0.00007105923],"domain_scores_gemma":[0.9994874,0.0001280922,0.0001559398,0.00005980243,0.00003715272,0.0001315728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8942948,0.002651531,0.03983353,0.0009686165,0.01202573,0.0002584496,0.0001187828,0.001691974,0.01011712,0.00011488,0.002222436,0.03570206],"study_design_scores_gemma":[0.570051,0.132365,0.259521,0.0002291705,0.0224764,0.001016352,0.0003574099,0.004079571,0.003957656,0.0007793793,0.005063165,0.00010399],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993831,0.002523379,0.0002752878,0.0002183491,0.00004854254,0.0005223394,0.001688895,0.00002468757,0.0008674099],"genre_scores_gemma":[0.9962339,0.0006491689,0.0002112412,0.0002504811,0.00007404143,0.0002841933,0.001807117,0.000008463423,0.0004814614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003128157,"threshold_uncertainty_score":0.01046479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06069596838321386,"score_gpt":0.4208892218136763,"score_spread":0.3601932534304624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}