{"id":"W3130158832","doi":"10.1016/s1474-4422(20)30449-x","title":"Detection of α-synuclein in CSF by RT-QuIC in patients with isolated rapid-eye-movement sleep behaviour disorder: a longitudinal observational study","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":332,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Weston Brain Institute; Scottish Government","keywords":"Dementia with Lewy bodies; Synucleinopathies; REM sleep behavior disorder; Lumbar puncture; Medicine; Polysomnography; Parkinson's disease; Internal medicine; Rapid eye movement sleep; Biomarker; Dementia; Lumbar; Disease; Cerebrospinal fluid; Oncology; Pathology; Gastroenterology; Alpha-synuclein; Surgery; Ophthalmology; Eye movement; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02847214730759507,"score_gpt":0.2693303833157553,"score_spread":0.2408582360081602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."},"direct_labels":[],"classifier":{"requested":true,"available":true,"version":"metacan-v1-d91a1de5be90","frame_rows_covered":4299418,"decision_targets":["metaresearch","metaepi_narrow","metaepi_broad","bibliometrics","sts","scholarly_communication","open_science","research_integrity","randomized_trial","nonrandomized_trial","observational","systematic_review","meta_analysis","case_report","qualitative","simulation_or_modeling","bench_or_experimental","theoretical_or_conceptual","not_applicable"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame.","warning":null},"prediction":{"classifier_version":"metacan-v1-d91a1de5be90","candidate_union":["nonrandomized_trial","observational"],"consensus_intersection":["observational"],"score_encoding":"uint16_le_65535","score_resolution":0.000015259021896696422,"scores":{"codex":{"metaresearch":0.0025177386129549098,"metaepi_narrow":0.000045777065690089265,"metaepi_broad":0.0003509575036240177,"bibliometrics":0.0001373311970702678,"sts":0.000045777065690089265,"scholarly_communication":0.00006103608758678569,"open_science":0.00025940337224383917,"research_integrity":0.00024414435034714275,"randomized_trial":0.0014953841458762494,"nonrandomized_trial":0.00019836728465705348,"observational":0.9982146944380865,"systematic_review":0.000030518043793392844,"meta_analysis":0.0003509575036240177,"case_report":0.0003356984817273213,"qualitative":0.0002136263065537499,"simulation_or_modeling":0.00012207217517357137,"bench_or_experimental":0.011490043488212406,"theoretical_or_conceptual":0,"not_applicable":0.000289921416037232,"design_other":0.0016327153429465172},"gemma":{"metaresearch":0.0001373311970702678,"metaepi_narrow":0.000045777065690089265,"metaepi_broad":0.00006103608758678569,"bibliometrics":0.000030518043793392844,"sts":0.000030518043793392844,"scholarly_communication":0.000015259021896696422,"open_science":0.000045777065690089265,"research_integrity":0.00007629510948348211,"randomized_trial":0.0006103608758678569,"nonrandomized_trial":0.0014038300144960708,"observational":0.9995422293430991,"systematic_review":0.000015259021896696422,"meta_analysis":0.0005493247882810712,"case_report":0.00016784924086366064,"qualitative":0.000030518043793392844,"simulation_or_modeling":0.00012207217517357137,"bench_or_experimental":0.002105745021744106,"theoretical_or_conceptual":0.000015259021896696422,"not_applicable":0.0010681315327687496}},"interpretation":"Scores imitate each teacher on the enriched screening sample; they are not calibrated prevalence probabilities for the full frame."}}