{"id":"W3130180415","doi":"10.1177/1352458521995484","title":"The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis","year":2021,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; National Multiple Sclerosis Society; Public Health Agency; European Commission; King's College London; National Institute of Neurological Disorders and Stroke; Jewish General Hospital; National Institute for Health and Care Research; Multiple Sclerosis Society of Canada; Public Health Agency of Canada; University of California, San Francisco; Cancer Research UK; Multiple Sclerosis Society; Wellcome Trust; Canadian Institutes of Health Research; Compute Canada","keywords":"Adiponectin; Mendelian randomization; Internal medicine; Medicine; Vitamin D and neurology; Leptin; Obesity; Endocrinology; Odds ratio; Body mass index; Confidence interval; Biology; Insulin resistance; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.003472694,0.0003796662,0.001116284,0.0007075333,0.001958843,0.0002656839,0.0002421423,0.0001995447,0.0001589174],"category_scores_gemma":[0.03363681,0.0002829851,0.000650873,0.002666539,0.0003319049,0.0003813673,0.0003341778,0.0008774787,0.00002214831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004863626,"about_ca_system_score_gemma":0.000275993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003431956,"about_ca_topic_score_gemma":0.002788206,"domain_scores_codex":[0.9947518,0.001278712,0.001303349,0.0005998717,0.001316199,0.0007501025],"domain_scores_gemma":[0.9904725,0.004391905,0.0007938846,0.0005801588,0.00306269,0.0006988485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001914343,0.0005831231,0.6867355,0.00004610414,0.005090937,0.000009524567,0.002791862,0.001560637,0.2758954,0.00005461684,0.001542117,0.02377585],"study_design_scores_gemma":[0.01613571,0.0002481338,0.9256023,0.0002765119,0.001597897,0.00002276975,0.001642625,0.01233223,0.04138365,0.00004600737,0.0004363969,0.0002758183],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587581,0.001813375,0.0326644,0.004706023,0.0002560329,0.001195751,0.0004305492,0.00005812206,0.0001176272],"genre_scores_gemma":[0.9814675,0.01220336,0.005562,0.0001096607,0.000226002,0.0001248987,0.00008879837,0.00004086027,0.0001769526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2388668,"threshold_uncertainty_score":0.9999622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04824777141505403,"score_gpt":0.2950074297474419,"score_spread":0.2467596583323879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}