{"id":"W3130180415","doi":"10.1177/1352458521995484","title":"The relative contributions of obesity, vitamin D, leptin, and adiponectin to multiple sclerosis risk: A Mendelian randomization mediation analysis","year":2021,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; National Institutes of Health; National Multiple Sclerosis Society; Public Health Agency; European Commission; King's College London; National Institute of Neurological Disorders and Stroke; Jewish General Hospital; National Institute for Health and Care Research; Multiple Sclerosis Society of Canada; Public Health Agency of Canada; University of California, San Francisco; Cancer Research UK; Multiple Sclerosis Society; Wellcome Trust; Canadian Institutes of Health Research; Compute Canada","keywords":"Adiponectin; Mendelian randomization; Internal medicine; Medicine; Vitamin D and neurology; Leptin; Obesity; Endocrinology; Odds ratio; Body mass index; Confidence interval; Biology; Insulin resistance; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02712114,0.002033114,0.002031497,0.001626684,0.0005509473,0.0009034455,0.001868572,0.0009806649,0.004863178],"category_scores_gemma":[0.03942289,0.0007216363,0.006016094,0.0009415066,0.0007248738,0.0006316322,0.001103493,0.001095938,0.0002592774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005750941,"about_ca_system_score_gemma":0.001044131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004057547,"about_ca_topic_score_gemma":0.001201686,"domain_scores_codex":[0.9711152,0.02475159,0.0005192106,0.001900781,0.001137418,0.0005758033],"domain_scores_gemma":[0.9716774,0.02453917,0.00159679,0.00152561,0.0004563218,0.0002048077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05026939,0.0009857359,0.6693994,0.001667161,0.1040899,0.003798329,0.001381072,0.0186735,0.008692003,0.02025619,0.003243642,0.1175436],"study_design_scores_gemma":[0.01663534,0.01553012,0.3386029,0.0005919952,0.1449176,0.009022903,0.0008817877,0.4068294,0.006538966,0.05083818,0.009218432,0.0003924445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8668091,0.005346687,0.1213642,0.001442677,0.0001806151,0.001059279,0.0008101368,0.0005491526,0.002438097],"genre_scores_gemma":[0.9759591,0.0005438491,0.02184975,0.0001652867,0.00006410764,0.0006444374,0.0001757063,0.00003166406,0.0005661109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02712114,"threshold_uncertainty_score":0.143432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04824777141505403,"score_gpt":0.2950074297474419,"score_spread":0.2467596583323879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}