{"id":"W3130243682","doi":"10.1158/1538-7445.sabcs20-pd13-09","title":"Abstract PD13-09: Impact of neratinib on outcomes in HER2-positive metastatic breast cancer patients with central nervous system disease at baseline: Findings from the phase 3 NALA trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Neratinib; Lapatinib; Metastatic breast cancer; Capecitabine; Clinical endpoint; Internal medicine; Oncology; Cancer; Breast cancer; Phases of clinical research; Gastroenterology; Randomized controlled trial; Trastuzumab; Clinical trial; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002515365,0.0006048763,0.00147671,0.0001761126,0.0002981645,0.001234634,0.0006531407,0.0009028303,0.003074712],"category_scores_gemma":[0.002452949,0.000173605,0.002234689,0.0003778828,0.0006034329,0.0008868572,0.0005074692,0.00247105,0.0006213448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009286732,"about_ca_system_score_gemma":0.001156487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006413776,"about_ca_topic_score_gemma":0.001841826,"domain_scores_codex":[0.9987971,0.0006763337,0.0001058324,0.0001844053,0.0001217826,0.000114471],"domain_scores_gemma":[0.9980574,0.0005622753,0.0005452454,0.0001514602,0.0001531392,0.0005304391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8936164,0.005695739,0.02308467,0.0009100818,0.005383127,0.0001083897,0.00009255012,0.001320567,0.004313318,0.0002069971,0.006183026,0.05908508],"study_design_scores_gemma":[0.6059678,0.2001063,0.1709587,0.0002890665,0.007192374,0.0006175008,0.0001774477,0.002732411,0.002801674,0.001233681,0.007808741,0.0001143835],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855061,0.005696061,0.0002745242,0.001086213,0.0001211673,0.0005702137,0.004151613,0.00004611179,0.002548002],"genre_scores_gemma":[0.9934832,0.001075991,0.0003086654,0.0006435686,0.000106956,0.0004742724,0.003227799,0.0000119764,0.0006675425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003074712,"threshold_uncertainty_score":0.01330268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05039416918420588,"score_gpt":0.4159013622418695,"score_spread":0.3655071930576637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}