{"id":"W3130279262","doi":"10.1021/jacs.0c12955","title":"The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis","year":2021,"lang":"en","type":"review","venue":"Journal of the American Chemical Society","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; Canadian Institutes of Health Research; Simons Foundation; Howard Hughes Medical Institute","keywords":"Nucleotide; Oligonucleotide; Chemistry; RNA; Nucleobase; Nucleic acid; Biochemistry; Stereochemistry; Combinatorial chemistry; Computational biology; DNA; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003745857,0.0002404026,0.001279396,0.000006370725,0.000134384,0.00002466548,0.001220114,0.00004536331,0.00009265979],"category_scores_gemma":[0.0001581107,0.0001032919,0.002436008,0.0004058334,0.0006616063,0.00003152853,0.0002450208,0.0005733234,0.000001550341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000502311,"about_ca_system_score_gemma":0.0004006153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001278817,"about_ca_topic_score_gemma":2.985193e-7,"domain_scores_codex":[0.9979698,0.0002304066,0.000963107,0.0001772051,0.0004430314,0.0002164501],"domain_scores_gemma":[0.9949355,0.0008972833,0.003264634,0.0006044297,0.0002354107,0.00006274091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002733583,0.0005328301,0.0007745627,0.001277843,0.007600913,0.000001432603,0.0004665358,0.0000570029,0.005977144,0.0002546969,0.1003416,0.882688],"study_design_scores_gemma":[0.0001057252,0.00004359902,0.00005710616,0.004483409,0.002651126,0.00001215008,0.0008808229,0.00002023784,0.02049562,0.0001691889,0.9707955,0.0002855424],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03589498,0.9619245,0.00003994998,0.00113801,0.0004530458,0.0002109177,0.000241045,0.000003331279,0.00009420818],"genre_scores_gemma":[0.06319925,0.9345242,0.000689475,0.0000543795,0.001430804,0.000005891408,0.00000375923,0.00003596443,0.00005631343],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8824025,"threshold_uncertainty_score":0.4212122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02087076612388764,"score_gpt":0.2832385906542546,"score_spread":0.2623678245303669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}