{"id":"W3130296736","doi":"10.1016/j.bpj.2020.11.1432","title":"Challenges with the Preparation of a Soluble and Active Form of LRAT","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Acyltransferase; Yield (engineering); Specific activity; Myristoylation; Enzyme; Biochemistry; Chromatography; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008783841,0.0007251118,0.001552824,0.0008521152,0.001086693,0.002793002,0.001887777,0.001951845,0.003281804],"category_scores_gemma":[0.0117208,0.0007864555,0.00118236,0.0006050576,0.001252562,0.001531954,0.001414944,0.005377427,0.00543852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001440267,"about_ca_system_score_gemma":0.002080182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001886004,"about_ca_topic_score_gemma":0.002975792,"domain_scores_codex":[0.9949712,0.002182543,0.0005669944,0.0004976262,0.001511211,0.0002705442],"domain_scores_gemma":[0.9899237,0.006020927,0.000483791,0.001083347,0.001906642,0.0005816345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004240494,0.0004298975,0.0008334543,0.002366371,0.0002711435,0.0006501211,0.001484214,0.001453354,0.9328609,0.00995912,0.01344063,0.03582675],"study_design_scores_gemma":[0.0002016279,0.0009845825,0.00321624,0.0004428055,0.0002744258,0.003539786,0.001797839,0.005620044,0.7191136,0.009240656,0.2554112,0.0001571258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3676569,0.0575221,0.4556341,0.0694817,0.01092297,0.004177408,0.005750152,0.002264505,0.02659012],"genre_scores_gemma":[0.5124625,0.03641372,0.3721755,0.01200937,0.002660554,0.003910041,0.01635163,0.001520469,0.04249625],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008783841,"threshold_uncertainty_score":0.04645395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191355971495906,"score_gpt":0.2592845374834807,"score_spread":0.2473709777685216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}