{"id":"W3130306790","doi":"10.1158/1538-7445.sabcs20-pd3-08","title":"Abstract PD3-08: Tucatinib vs placebo in combination with trastuzumab and capecitabine for patients with locally advanced unresectable or HER2-positive metastatic breast cancer (HER2CLIMB): Outcomes by hormone receptor status","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Medicine; Capecitabine; Internal medicine; Metastatic breast cancer; Pertuzumab; Oncology; Trastuzumab; Placebo; Breast cancer; Regimen; Progression-free survival; Neratinib; Cancer; Chemotherapy; Colorectal cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001682262,0.001293691,0.003141065,0.0005363359,0.0003945832,0.001260308,0.0009099737,0.001382029,0.006547988],"category_scores_gemma":[0.001541291,0.0004243523,0.002658521,0.0005625863,0.001190346,0.000997215,0.0005615903,0.003626483,0.0006823231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001016121,"about_ca_system_score_gemma":0.001513563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004981,"about_ca_topic_score_gemma":0.001940858,"domain_scores_codex":[0.9988233,0.0006551595,0.00008990767,0.0001514885,0.00008166973,0.0001983646],"domain_scores_gemma":[0.9990709,0.0002442876,0.0002198042,0.00004976412,0.00004950345,0.000365622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9851145,0.003639501,0.0003787156,0.0001598824,0.0004967009,0.00001788348,0.00001272857,0.0002596906,0.001429514,0.00004486193,0.0003548595,0.008091221],"study_design_scores_gemma":[0.7550074,0.2371598,0.003815046,0.00003935517,0.001016006,0.00003676069,0.00002844647,0.0008372584,0.00111601,0.0002769132,0.0006470933,0.00001989747],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890006,0.003624409,0.0004489843,0.0006174677,0.0003881672,0.002133113,0.00140429,0.00009918822,0.002283879],"genre_scores_gemma":[0.9947397,0.0008222069,0.0004488639,0.0004858589,0.0002632402,0.001290337,0.0006159164,0.000009230178,0.001324656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006547988,"threshold_uncertainty_score":0.02190518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02296868325512378,"score_gpt":0.3564962812160818,"score_spread":0.333527597960958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}