{"id":"W3130327672","doi":"10.1158/1538-7445.sabcs20-ps5-12","title":"Abstract PS5-12: Preliminary correlative analysis of clinical outcomes with <i>PIK3CA</i> mutation (mut) status from a phase I/Ib study of GDC-0077 in patients (pts) with hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Fulvestrant; Medicine; Letrozole; Internal medicine; Palbociclib; Oncology; Cancer; Breast cancer; Estrogen receptor; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009511068,0.000418937,0.000514748,0.0003484031,0.0002105831,0.000545776,0.0003100288,0.0003177928,0.002871706],"category_scores_gemma":[0.0007068272,0.0001353715,0.0004683091,0.0004294544,0.0003866878,0.000358141,0.0002869227,0.000685426,0.00047994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005746249,"about_ca_system_score_gemma":0.0007883309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222549,"about_ca_topic_score_gemma":0.002944572,"domain_scores_codex":[0.9996864,0.00009268564,0.00002579762,0.00007219736,0.00006867709,0.00005434484],"domain_scores_gemma":[0.9993687,0.0001016924,0.0001423475,0.00004270056,0.00005680432,0.0002876799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2696926,0.008018482,0.4859397,0.0004937135,0.001196713,0.0003995254,0.0002403253,0.002292893,0.1058353,0.0001438651,0.004491678,0.1212553],"study_design_scores_gemma":[0.01143185,0.1135488,0.8465444,0.00002531351,0.001044623,0.0007783169,0.0001531305,0.001357672,0.02040264,0.000167733,0.004513779,0.00003181606],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953001,0.0005384793,0.00024153,0.00008396225,0.000009574247,0.0002560534,0.00217633,0.00003194534,0.001362102],"genre_scores_gemma":[0.9932044,0.0001882275,0.0004149555,0.0001367831,0.00002030972,0.0001795157,0.004854693,0.000009495644,0.0009917503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002871706,"threshold_uncertainty_score":0.009606779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06948872393345283,"score_gpt":0.4526514672675588,"score_spread":0.3831627433341059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}