{"id":"W3130327672","doi":"10.1158/1538-7445.sabcs20-ps5-12","title":"Abstract PS5-12: Preliminary correlative analysis of clinical outcomes with <i>PIK3CA</i> mutation (mut) status from a phase I/Ib study of GDC-0077 in patients (pts) with hormone receptor-positive/HER2-negative metastatic breast cancer (HR+/HER2- mBC)","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Fulvestrant; Medicine; Letrozole; Internal medicine; Palbociclib; Oncology; Cancer; Breast cancer; Estrogen receptor; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008875223,0.0004643388,0.002046827,0.0007550576,0.0001189894,0.0000278245,0.0002488547,0.0001355489,0.001142289],"category_scores_gemma":[0.000371508,0.0003497618,0.0002215577,0.003422345,0.0008457598,0.0004259308,0.000134056,0.001187591,0.00000561411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026265,"about_ca_system_score_gemma":0.001927558,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0324639,"about_ca_topic_score_gemma":0.0171062,"domain_scores_codex":[0.9934495,0.001060169,0.001395062,0.00112341,0.002197929,0.0007739458],"domain_scores_gemma":[0.9927942,0.002106985,0.0008726305,0.0007682781,0.003079007,0.000378949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06289613,0.0117806,0.8479089,0.0001409912,0.01229917,0.000276515,0.01760975,0.002952499,0.001083452,0.000003632128,0.0000672444,0.04298113],"study_design_scores_gemma":[0.03349826,0.007998224,0.9328558,0.0008011096,0.002115757,0.000003034187,0.02013425,0.0001715674,0.002051587,0.00002652134,0.00002331271,0.0003206001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926915,0.0009329535,0.0002014986,0.0002712461,0.000083632,0.002258863,0.003406131,0.00002494956,0.0001292044],"genre_scores_gemma":[0.9968963,0.0005097624,0.001074523,0.00007206196,0.00005988732,0.0006195641,0.0005091545,0.00009165145,0.0001670717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08494688,"threshold_uncertainty_score":0.9998955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06948872393345283,"score_gpt":0.4526514672675588,"score_spread":0.3831627433341059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}