{"id":"W3130363432","doi":"10.1038/s41467-021-21371-5","title":"Lentivirus-mediated gene therapy for Fabry disease","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Foothills Medical Centre; Alberta Health Services; Nova Scotia Health Authority; Princess Margaret Cancer Centre; University of Calgary; Hôpital Fleurimont; McMaster University; Alberta Children's Hospital; Juravinski Hospital; Western University; University of Toronto; Université de Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University Health Network; Children’s Health Research Institute","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Kidney Foundation of Canada; Government of Canada; Midwest Athletes Against Childhood Cancer","keywords":"Lentivirus; Fabry disease; Genetic enhancement; Gene; Disease; Virology; Medicine; Genetics; Biology; Human immunodeficiency virus (HIV); Viral disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001362388,0.0001015109,0.0001602015,0.00007347969,0.0002531947,0.00002922698,0.0004578456,0.0001724823,0.0001371083],"category_scores_gemma":[0.001103201,0.00009257904,0.000148643,0.0004330507,0.0001143176,0.00006150375,0.000202025,0.0006707243,0.00005081658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006528588,"about_ca_system_score_gemma":0.000438909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007047281,"about_ca_topic_score_gemma":0.00006693846,"domain_scores_codex":[0.9990801,0.0001078157,0.0001514715,0.0002047675,0.0002484536,0.0002074425],"domain_scores_gemma":[0.9968805,0.0003972822,0.00003720209,0.001915858,0.0005841782,0.0001850179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003435231,0.01365102,0.2104689,0.0004429769,0.002041424,0.0002824751,0.00190963,0.000007577246,0.257102,0.04132923,0.2726986,0.1966309],"study_design_scores_gemma":[0.003691243,0.00008812828,0.1068703,0.00004903521,0.00008439906,0.00001557878,0.0001836753,0.001104609,0.005621372,0.000842015,0.8812222,0.0002273953],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3266549,0.468646,0.002106595,0.1819089,0.0004800016,0.003701249,0.0008875118,0.0004786832,0.01513612],"genre_scores_gemma":[0.9805404,0.008136228,0.004363299,0.002755289,0.00007382645,0.0002736681,0.002163386,0.00003144065,0.001662449],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6538855,"threshold_uncertainty_score":0.3775264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304183996082435,"score_gpt":0.379958940949359,"score_spread":0.3269171009885347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}