{"id":"W3130363432","doi":"10.1038/s41467-021-21371-5","title":"Lentivirus-mediated gene therapy for Fabry disease","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Foothills Medical Centre; Alberta Health Services; Nova Scotia Health Authority; Princess Margaret Cancer Centre; University of Calgary; Hôpital Fleurimont; McMaster University; Alberta Children's Hospital; Juravinski Hospital; Western University; University of Toronto; Université de Sherbrooke; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; University Health Network; Children’s Health Research Institute","funders":"Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary; Kidney Foundation of Canada; Government of Canada; Midwest Athletes Against Childhood Cancer","keywords":"Lentivirus; Fabry disease; Genetic enhancement; Gene; Disease; Virology; Medicine; Genetics; Biology; Human immunodeficiency virus (HIV); Viral disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004453621,0.0003343108,0.0004577163,0.0002614058,0.000170307,0.0004007026,0.0003267596,0.0004992323,0.001663879],"category_scores_gemma":[0.0001497143,0.0001062955,0.0002937179,0.0001590793,0.0004190521,0.0002187683,0.0001843179,0.0007836097,0.0002139777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003496895,"about_ca_system_score_gemma":0.0002631214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005632031,"about_ca_topic_score_gemma":0.0005743264,"domain_scores_codex":[0.9998616,0.00004640989,0.000008016979,0.00001984013,0.00003079935,0.00003341456],"domain_scores_gemma":[0.999939,0.00001643082,0.00001520413,0.000009681386,0.000003381204,0.00001637376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01383201,0.01304087,0.002674232,0.0003496687,0.0002098167,0.0006295909,0.0002098207,0.002354763,0.8649809,0.002212188,0.002158683,0.09734744],"study_design_scores_gemma":[0.02418806,0.3165714,0.01784073,0.000103413,0.000435699,0.003032984,0.0001539363,0.01004225,0.6057869,0.0008047401,0.02099612,0.00004390391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950504,0.00124408,0.001699275,0.0001299693,0.00005565906,0.0003852889,0.0002024587,0.00008723859,0.001145769],"genre_scores_gemma":[0.9967341,0.0006484365,0.0009881604,0.00005947146,0.00001744883,0.0001992519,0.000241014,0.000006906726,0.001105119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663879,"threshold_uncertainty_score":0.005566299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304183996082435,"score_gpt":0.379958940949359,"score_spread":0.3269171009885347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}