{"id":"W3130422896","doi":"10.1186/s12964-020-00688-6","title":"Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities","year":2021,"lang":"en","type":"review","venue":"Cell Communication and Signaling","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Chinese Academy of Medical Sciences; China Scholarship Council; Alzheimer’s Research UK","keywords":"Inflammasome; Context (archaeology); Ubiquitin; Caspase 1; Kinase; Drug development; Drug target; Signal transducing adaptor protein; Signal transduction; Biology; Cell biology; Computational biology; Drug; Neuroscience; Bioinformatics; Inflammation; Immunology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000322785,0.0005876566,0.000818564,0.001163497,0.0001807485,0.0007057253,0.000502398,0.0008122215,0.003698269],"category_scores_gemma":[0.0003206368,0.0001437058,0.0003573971,0.00112173,0.0002955694,0.0009754545,0.0004716741,0.001423533,0.002002198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004029534,"about_ca_system_score_gemma":0.0004959984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004411977,"about_ca_topic_score_gemma":0.0009885248,"domain_scores_codex":[0.9999173,0.00001319482,0.000009960183,0.00001538156,0.00002990317,0.00001419505],"domain_scores_gemma":[0.9998661,0.00005452303,0.00002004989,0.000005026364,0.00003746001,0.00001685715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001344359,0.00006758224,0.0001524169,0.01230858,0.0000633721,0.000477321,0.00004942748,0.0003478612,0.006150031,0.005174017,0.04387875,0.9311962],"study_design_scores_gemma":[0.00002244856,0.0001277801,0.0006077085,0.00178046,0.00008893757,0.002028384,0.00004274342,0.0001429326,0.001838258,0.002028462,0.991273,0.00001885283],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002071013,0.997651,0.0002178864,0.0003808873,0.0002961644,0.000003860879,0.00003194458,0.00001269361,0.001198591],"genre_scores_gemma":[0.001218035,0.9973618,0.0002095373,0.0002416553,0.000227972,0.000005875509,0.00005159806,0.000002133801,0.0006814277],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003698269,"threshold_uncertainty_score":0.0123719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224887274360877,"score_gpt":0.3068281744609792,"score_spread":0.2745793017173704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}