{"id":"W3130422896","doi":"10.1186/s12964-020-00688-6","title":"Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities","year":2021,"lang":"en","type":"review","venue":"Cell Communication and Signaling","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Chinese Academy of Medical Sciences; China Scholarship Council; Alzheimer’s Research UK","keywords":"Inflammasome; Context (archaeology); Ubiquitin; Caspase 1; Kinase; Drug development; Drug target; Signal transducing adaptor protein; Signal transduction; Biology; Cell biology; Computational biology; Drug; Neuroscience; Bioinformatics; Inflammation; Immunology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006679418,0.000316031,0.0006654984,0.00009569764,0.0005159234,0.0001437641,0.000525204,0.0002326922,0.00006005864],"category_scores_gemma":[0.00008908589,0.0002529526,0.0003168151,0.0001149315,0.000132873,0.0000212184,0.0001743025,0.0003765677,0.000004086865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000163912,"about_ca_system_score_gemma":0.0002382047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001605345,"about_ca_topic_score_gemma":0.000002943327,"domain_scores_codex":[0.9979104,0.0007237273,0.000726416,0.0002947417,0.0001544224,0.0001903151],"domain_scores_gemma":[0.9981752,0.0003101281,0.0004985615,0.0007281086,0.0002382312,0.0000497454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001459565,0.0002611705,0.00006066808,0.003884286,0.002264557,0.000001291245,0.003668112,0.0002001211,0.0212498,0.002095477,0.01053403,0.9556345],"study_design_scores_gemma":[0.0006601465,0.00001743878,0.000001622374,0.0008545534,0.0002608293,0.000002424806,0.001359483,0.00004671159,0.002054719,0.00005076492,0.9943663,0.000325034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001178134,0.9951072,0.001052467,0.000536305,0.00003725085,0.0006531558,0.00006651413,0.00001596773,0.00135306],"genre_scores_gemma":[0.01492227,0.9702561,0.0002184273,0.0001568905,0.00008284012,0.0002268837,0.01261268,0.00004470293,0.00147917],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9838322,"threshold_uncertainty_score":0.9999923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224887274360877,"score_gpt":0.3068281744609792,"score_spread":0.2745793017173704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}