{"id":"W3130441427","doi":"10.1002/rth2.12476","title":"Extended half‐life factor VIII concentrates in adults with hemophilia A: Comparative pharmacokinetics of two products","year":2021,"lang":"en","type":"article","venue":"Research and Practice in Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; McMaster University; University of Toronto; St. Michael's Hospital","funders":"","keywords":"Pharmacokinetics; Volume of distribution; Medicine; Population; In vivo; Statistical significance; Recombinant DNA; Half-life; Pharmacology; Clearance; Internal medicine; Chemistry; Urology; Biology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001047641,0.0002164526,0.0004283403,0.0003222521,0.0001232383,0.0004543395,0.0001233079,0.0003460172,0.0007367294],"category_scores_gemma":[0.002279253,0.0001081137,0.0003230208,0.0002503447,0.0002032579,0.000417308,0.0001961484,0.0003181742,0.000123251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320826,"about_ca_system_score_gemma":0.0002085661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003961601,"about_ca_topic_score_gemma":0.0002428602,"domain_scores_codex":[0.9995559,0.0001535881,0.00004634997,0.0001164177,0.0000984903,0.00002913721],"domain_scores_gemma":[0.9987195,0.0005462057,0.0004210543,0.00007852086,0.0001121643,0.0001226132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04052076,0.0009237184,0.8577509,0.0001903798,0.0009029452,0.0007216334,0.0005981941,0.001378912,0.01789232,0.0001789564,0.0003009152,0.07864042],"study_design_scores_gemma":[0.0009051293,0.04248631,0.9423097,0.00003302522,0.0007492731,0.003775356,0.0002918205,0.002261606,0.005484063,0.0001283139,0.00155098,0.00002441796],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998817,0.000863752,0.000129976,0.00001087738,0.000001678656,0.000009034808,0.00004505224,0.000001974943,0.0001207176],"genre_scores_gemma":[0.9994304,0.0002718837,0.0001283661,0.00001516022,0.000006394276,0.00000932402,0.0001060931,0.000001125254,0.00003118403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001047641,"threshold_uncertainty_score":0.00554055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2199878212697196,"score_gpt":0.4781597704759143,"score_spread":0.2581719492061947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}