{"id":"W3130483070","doi":"10.1021/acs.molpharmaceut.9b01200","title":"In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na<sup>+</sup>-Taurocholate Cotransporting Polypeptide (NTCP, <i>SLC10A1</i>)","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Karolinska Institutet","keywords":"In silico; Rosuvastatin; Transporter; Taurocholic acid; Chemistry; Organic anion transporter 1; In vitro; HEK 293 cells; Bile acid; Biology; Biochemistry; Pharmacology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008765775,0.0007231316,0.0007120818,0.0002929874,0.0002450534,0.0007377698,0.0004053436,0.0006778693,0.0005390065],"category_scores_gemma":[0.001823449,0.0002126977,0.0008408934,0.0002875847,0.0002172269,0.0001802021,0.0002088815,0.0004400616,0.0002517788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006259669,"about_ca_system_score_gemma":0.0004919021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003830951,"about_ca_topic_score_gemma":0.003816009,"domain_scores_codex":[0.9995919,0.0001475286,0.00004419244,0.00009455202,0.00008351073,0.0000383113],"domain_scores_gemma":[0.9993199,0.000441879,0.00007557309,0.00003817762,0.00009297307,0.00003164438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001537352,0.0004786587,0.04104008,0.0005508676,0.0005067661,0.0008385974,0.0001537868,0.4932311,0.439772,0.0008342935,0.0006446053,0.02041191],"study_design_scores_gemma":[0.00004964674,0.0006554864,0.008825486,0.00001969203,0.0001962133,0.0003264645,0.00007287395,0.8601011,0.1284794,0.0002129623,0.001034401,0.00002630071],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852822,0.000407365,0.01249675,0.0000887999,0.00002321267,0.00003212548,0.0008450653,0.0002339147,0.0005905626],"genre_scores_gemma":[0.9718211,0.0004252697,0.02435306,0.00005846218,0.000007766804,0.00004610695,0.002847764,0.00006169709,0.0003788687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003830951,"threshold_uncertainty_score":0.007617295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643052442870145,"score_gpt":0.2397883220414377,"score_spread":0.2233577976127362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}