{"id":"W3130483070","doi":"10.1021/acs.molpharmaceut.9b01200","title":"In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na<sup>+</sup>-Taurocholate Cotransporting Polypeptide (NTCP, <i>SLC10A1</i>)","year":2020,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Karolinska Institutet","keywords":"In silico; Rosuvastatin; Transporter; Taurocholic acid; Chemistry; Organic anion transporter 1; In vitro; HEK 293 cells; Bile acid; Biology; Biochemistry; Pharmacology; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003010909,0.0001857101,0.0002902334,0.0001645916,0.00003590481,0.00001388499,0.00006538552,0.00009815059,0.00001905181],"category_scores_gemma":[0.00001309941,0.0001664784,0.00005260082,0.0004753761,0.00005094512,0.0001427788,0.000007151913,0.0003535683,5.564089e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003088731,"about_ca_system_score_gemma":0.00005534487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000185968,"about_ca_topic_score_gemma":0.00000894897,"domain_scores_codex":[0.998462,0.0000910915,0.0005835189,0.0003255826,0.0003151261,0.0002226549],"domain_scores_gemma":[0.9996089,0.00002063243,0.0001194321,0.0001160536,0.00004029901,0.0000946204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007965958,0.0001306994,0.0314505,0.0003304117,0.00002160342,0.000211799,0.005700198,0.001055431,0.9589186,0.00001242618,0.000001267801,0.001370496],"study_design_scores_gemma":[0.005659783,0.00008627291,0.4917136,0.0001840304,0.0002160814,0.00003756632,0.000491541,0.05095313,0.4498963,0.00003687484,0.0005199428,0.0002048919],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849371,0.0006818641,0.01203839,0.001505851,0.00005522133,0.0006588184,0.00008602078,0.0000209641,0.00001582044],"genre_scores_gemma":[0.9969812,0.0004634394,0.0004174837,0.00171219,0.00004760595,0.00003184065,0.0003087653,0.00002717382,0.00001032749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5090223,"threshold_uncertainty_score":0.6788793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01643052442870145,"score_gpt":0.2397883220414377,"score_spread":0.2233577976127362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}