{"id":"W3130496612","doi":"10.1152/ajpcell.00594.2020","title":"Temporal manipulation of KCC3 expression in juvenile or adult mice suggests irreversible developmental deficit in hereditary motor sensory neuropathy with agenesis of the corpus callosum","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Hereditary motor and sensory neuropathy; Agenesis of the corpus callosum; Juvenile; Biology; Disease; Neuroscience; Corpus callosum; Internal medicine; Medicine; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482229,0.0002866409,0.0009099832,0.0002112604,0.00005893655,0.000002852163,0.0005661411,0.0001069493,0.0001034015],"category_scores_gemma":[0.0005125355,0.0001846785,0.0001534914,0.0009663275,0.001040166,0.000170446,0.000212338,0.0005240357,0.000003843016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006807947,"about_ca_system_score_gemma":0.0003580813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002197885,"about_ca_topic_score_gemma":0.0001446876,"domain_scores_codex":[0.99617,0.001634349,0.0009681413,0.0005202416,0.0003014452,0.00040578],"domain_scores_gemma":[0.9974148,0.0007853066,0.001238213,0.0002960572,0.0001812152,0.00008440475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00220772,0.0005680639,0.01156222,0.00006405333,0.00000824847,0.0001906165,0.0002559869,0.00432518,0.980505,0.000005968256,0.00009834936,0.0002086081],"study_design_scores_gemma":[0.001666446,0.002359391,0.472516,0.0001185736,0.00001859791,0.0002026952,0.001220143,0.0002273325,0.5212125,0.000209304,0.00004024284,0.0002088276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991009,0.00006217726,0.000006840854,0.0002114895,0.0003035693,0.0002009382,0.00003030869,0.000008707584,0.00007507153],"genre_scores_gemma":[0.9984151,0.0001109937,0.0006350728,0.0007009846,0.00005688212,0.000006969349,0.000006307193,0.00002853957,0.00003918748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4609538,"threshold_uncertainty_score":0.7530969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01926006565768286,"score_gpt":0.2286879439418736,"score_spread":0.2094278782841907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}