{"id":"W3130514573","doi":"10.1016/j.antiviral.2021.105046","title":"Differential impact of various substitutions at codon 715 in region II of HSV-1 and HCMV DNA polymerases","year":2021,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Institute of Infection and Immunity","keywords":"Foscarnet; Ganciclovir; DNA polymerase; Virology; Mutant; Biology; Human cytomegalovirus; Recombinant DNA; Herpes simplex virus; Molecular biology; DNA; Mutation; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000130338,0.00008267607,0.000257858,0.0002637588,0.000134236,0.000007593536,0.00003276965,0.00007541489,0.0001084254],"category_scores_gemma":[0.0001928329,0.00006482861,0.00009323805,0.0005160987,0.0002686892,0.00006057729,0.0001294154,0.0001792422,0.000007237451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001321566,"about_ca_system_score_gemma":0.0002921284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004661163,"about_ca_topic_score_gemma":0.0008362061,"domain_scores_codex":[0.9989505,0.0001402449,0.0001960143,0.0001874125,0.0002781254,0.0002476838],"domain_scores_gemma":[0.9993837,0.0001375131,0.00003358621,0.0002215916,0.0001672352,0.00005634412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005002281,0.001904692,0.7207423,0.00009698509,0.0002179868,0.0004799628,0.0004225627,6.438941e-7,0.2574194,0.0008043597,0.0003533813,0.01705747],"study_design_scores_gemma":[0.002023889,0.0009320975,0.6638301,0.0002109961,0.00003411101,0.0000751456,0.0000609331,0.00006442362,0.3323671,0.000117774,0.0002199014,0.00006354452],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961666,0.0004392002,0.00001587234,0.0001269648,0.00002890519,0.0001722431,0.00002919071,0.000006704744,0.003014311],"genre_scores_gemma":[0.9977324,0.0006214437,0.00001453164,0.000003539945,0.00002404769,0.000007567689,0.00003376967,0.000008486732,0.001554205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07494762,"threshold_uncertainty_score":0.7046315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08317647964692601,"score_gpt":0.4219839951050883,"score_spread":0.3388075154581622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}