{"id":"W3130526148","doi":"10.3389/fnins.2021.630502","title":"APOE and Alzheimer’s Disease: From Lipid Transport to Physiopathology and Therapeutics","year":2021,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":339,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Université de Sherbrooke","keywords":"Apolipoprotein E; Allele; Pathogenesis; Cerebrospinal fluid; Central nervous system; Disease; Alzheimer's disease; Neuroscience; Biology; Medicine; Gene; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004260099,0.0007666591,0.001060372,0.001459101,0.0002600436,0.001004821,0.0006412385,0.0009558867,0.004018946],"category_scores_gemma":[0.000458548,0.0001881333,0.0003895324,0.001423297,0.0003631448,0.001180103,0.0006251971,0.001581816,0.002325349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005711984,"about_ca_system_score_gemma":0.001055918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008206321,"about_ca_topic_score_gemma":0.001556229,"domain_scores_codex":[0.9998758,0.00002237224,0.00001420799,0.00001868832,0.00005066707,0.00001834004],"domain_scores_gemma":[0.9998641,0.00005065068,0.00001706495,0.000004718689,0.00004266326,0.00002079753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001188203,0.0001090481,0.0001338486,0.01635355,0.00007189394,0.0002319471,0.0000937833,0.0002834737,0.002761027,0.006130252,0.04230807,0.9314042],"study_design_scores_gemma":[0.00001790592,0.000101711,0.0004985622,0.00299717,0.00005708204,0.00063101,0.00004978205,0.00005525062,0.0003176353,0.002408526,0.992855,0.0000103891],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001222769,0.998156,0.00006823144,0.0002685151,0.0002509756,0.000003717671,0.00001451252,0.000006189365,0.001109523],"genre_scores_gemma":[0.000545909,0.998214,0.00009137196,0.0001494638,0.0001632743,0.000004165404,0.00002193144,9.510636e-7,0.0008089855],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004018946,"threshold_uncertainty_score":0.01344466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07684992097480423,"score_gpt":0.3705336174577368,"score_spread":0.2936836964829326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}