{"id":"W3130635418","doi":"10.1111/bcp.14792","title":"Repurposing of thalidomide and its derivatives for the treatment of SARS‐coV‐2 infections: Hints on molecular action","year":2021,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Research (Canada); Hospital for Sick Children","funders":"","keywords":"Thalidomide; Drug repositioning; Lenalidomide; Pneumonia; Immunology; Angiogenesis; Repurposing; Medicine; Immune system; Transcriptome; Drug; Pharmacology; Biology; Cancer research; Multiple myeloma; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282648,0.000196658,0.0002522928,0.00023968,0.0001014639,0.0004762652,0.0001428152,0.0002168217,0.001293616],"category_scores_gemma":[0.0000938919,0.00006824009,0.0002692626,0.0001701507,0.0001377928,0.0002294118,0.0001299719,0.0004354616,0.000223186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002164208,"about_ca_system_score_gemma":0.0002049715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002850281,"about_ca_topic_score_gemma":0.0007311905,"domain_scores_codex":[0.9999467,0.00001189755,0.000004254888,0.00001015561,0.00001504911,0.00001196585],"domain_scores_gemma":[0.999969,0.000004652085,0.00001035127,0.000003088465,0.000007478675,0.000005344141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001313153,0.0002055453,0.002354498,0.0009882242,0.00009578685,0.0005025681,0.00009891806,0.0009810214,0.8905995,0.001059074,0.001271738,0.10053],"study_design_scores_gemma":[0.0004308829,0.008180879,0.05108561,0.0003653266,0.0005480973,0.004284904,0.0004741598,0.003868756,0.7651677,0.002229165,0.1632802,0.00008442809],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7383019,0.2438194,0.005915605,0.002195959,0.0002210852,0.0001521322,0.001313955,0.0001305383,0.007949495],"genre_scores_gemma":[0.9224366,0.06727166,0.005650503,0.000703973,0.0000971435,0.00005967392,0.0009539577,0.00001834012,0.002808096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001293616,"threshold_uncertainty_score":0.004327595,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2142998658766505,"score_gpt":0.5288995026849976,"score_spread":0.3145996368083472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}