{"id":"W3130642157","doi":"10.3390/ph14020160","title":"Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fondation ARC pour la Recherche sur le Cancer","keywords":"In vitro; In vivo; Kinase; MAPK/ERK pathway; Chemistry; Phosphorylation; Protein kinase A; Tumor microenvironment; MEK inhibitor; Mechanism of action; Small molecule; Cancer research; Pharmacology; Biochemistry; Biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008686003,0.0001900476,0.0001025847,0.00008608049,0.00006188462,0.0001863409,0.0002628817,0.0002408054,0.0006471426],"category_scores_gemma":[0.00008255374,0.00007813986,0.0001587922,0.00004615978,0.0001383486,0.0001670074,0.00008319275,0.0002612172,0.0002608404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001975642,"about_ca_system_score_gemma":0.00009641836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482883,"about_ca_topic_score_gemma":0.0001790643,"domain_scores_codex":[0.9999629,0.00000480157,0.000003261421,0.00001105435,0.00001032647,0.000007616211],"domain_scores_gemma":[0.9999526,0.000004925295,0.00001864429,0.000004486371,0.000008033858,0.00001150162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001070238,0.00004597905,0.0001110098,0.00004247054,0.00000413432,0.00005786291,0.00001117516,0.0001929689,0.9964644,0.0001862052,0.00003354385,0.002743183],"study_design_scores_gemma":[0.0000428094,0.0009719852,0.0006141448,0.000002391005,0.00001247521,0.0002196729,0.000006188117,0.001015032,0.9939381,0.00002362773,0.003147807,0.000005887368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889832,0.0009367322,0.007714429,0.00009974481,0.00002780042,0.0001233098,0.0001591455,0.00006022692,0.001895359],"genre_scores_gemma":[0.9876589,0.0004576318,0.009554931,0.00005929726,0.00001010486,0.00008130033,0.0001792821,0.000008436264,0.001990046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006471426,"threshold_uncertainty_score":0.00216496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07362752306742701,"score_gpt":0.3304361107984232,"score_spread":0.2568085877309961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}