{"id":"W3130642157","doi":"10.3390/ph14020160","title":"Design and Mechanism of Action of a New Prototype of Combi-Molecule “Programed” to Release Bioactive Species at a pH Range Akin to That of the Tumor Microenvironment","year":2021,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fondation ARC pour la Recherche sur le Cancer","keywords":"In vitro; In vivo; Kinase; MAPK/ERK pathway; Chemistry; Phosphorylation; Protein kinase A; Tumor microenvironment; MEK inhibitor; Mechanism of action; Small molecule; Cancer research; Pharmacology; Biochemistry; Biology; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381054,0.0001129636,0.0002192942,0.00002738143,0.00002101809,0.000003624683,0.0001141646,0.00004690307,0.00005714863],"category_scores_gemma":[0.00002474439,0.00009387723,0.00008579528,0.0001097806,0.00007499507,0.00000221343,0.0002006036,0.00004692615,7.395933e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002271636,"about_ca_system_score_gemma":0.0000741633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000194632,"about_ca_topic_score_gemma":0.000008329122,"domain_scores_codex":[0.9991682,0.00009101904,0.0002099058,0.0002190023,0.0001678595,0.0001440366],"domain_scores_gemma":[0.9994172,0.00001823674,0.0001378974,0.000251814,0.00006595307,0.0001089185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001608454,0.0001704119,0.00005861051,0.00008904139,0.0001050411,0.000001110263,0.0002421284,0.00001922984,0.9952946,0.0003024314,0.00004956252,0.002059412],"study_design_scores_gemma":[0.0008323039,0.0007446616,0.0001610302,0.00005011987,0.00009506949,0.000006356649,0.0001400747,0.00003275106,0.9913062,0.0002092097,0.006334825,0.00008738552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978586,0.0008044165,0.01848788,0.000547559,0.00007431805,0.001394551,0.00005281432,0.000002391577,0.00005004994],"genre_scores_gemma":[0.9956999,0.0003434692,0.00324086,0.0004168475,0.00001715257,0.00005748669,0.000003879577,0.00001523057,0.0002051711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01711388,"threshold_uncertainty_score":0.3828202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07362752306742701,"score_gpt":0.3304361107984232,"score_spread":0.2568085877309961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}