{"id":"W3130648111","doi":"10.1021/acs.jmedchem.0c01846","title":"Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; In vivo; BRD4; In vitro; Ubiquitin; Fusion protein; Small molecule; Proteasome; Proteolysis; Cell biology; Cancer research; Biochemistry; Biology; DNA; Recombinant DNA; Bromodomain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002444849,0.0002914929,0.00027186,0.0002447559,0.00007423712,0.0002429631,0.0001913871,0.0002882638,0.0007732796],"category_scores_gemma":[0.0001173156,0.0001187069,0.0001915684,0.000131649,0.0001424593,0.0001732152,0.0001102995,0.0003469368,0.0002075096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003700702,"about_ca_system_score_gemma":0.0002079422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007051529,"about_ca_topic_score_gemma":0.0006858468,"domain_scores_codex":[0.9998733,0.00002847182,0.00000994016,0.00002384293,0.00003066156,0.00003388023],"domain_scores_gemma":[0.9999194,0.00001331692,0.00003208311,0.00001038504,0.000009251026,0.00001553826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001194607,0.00007452414,0.00007222989,0.00003927772,0.00000788905,0.0000347639,0.000009112738,0.0003009771,0.9965855,0.0001085186,0.00005639064,0.002591384],"study_design_scores_gemma":[0.00003549401,0.0004339996,0.0004450861,0.000001693848,0.00001039805,0.000108601,0.000002519442,0.0007138261,0.9970086,0.000007316839,0.001229989,0.000002519444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891418,0.002313273,0.006406757,0.00008224786,0.00002659551,0.0001107875,0.000315603,0.0001080516,0.001494795],"genre_scores_gemma":[0.9931422,0.0008558493,0.003842772,0.00002855736,0.000006095132,0.00003353247,0.0002695107,0.00001288813,0.001808578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007732796,"threshold_uncertainty_score":0.00268507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00760972967771946,"score_gpt":0.2506375910902854,"score_spread":0.2430278614125659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}