{"id":"W3130648111","doi":"10.1021/acs.jmedchem.0c01846","title":"Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy","year":2021,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; In vivo; BRD4; In vitro; Ubiquitin; Fusion protein; Small molecule; Proteasome; Proteolysis; Cell biology; Cancer research; Biochemistry; Biology; DNA; Recombinant DNA; Bromodomain","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003222741,0.0001050712,0.0003044924,0.00005614541,0.0000119924,0.000004701325,0.00007935396,0.0001058871,0.00002119958],"category_scores_gemma":[0.0003239809,0.00009576707,0.00006525728,0.0001569838,0.0000897799,0.00001207058,0.00003883586,0.0001814995,6.509937e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002021872,"about_ca_system_score_gemma":0.0002590207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001591787,"about_ca_topic_score_gemma":0.00000475788,"domain_scores_codex":[0.9989534,0.00003759445,0.0005059981,0.0001450924,0.0002362738,0.0001216493],"domain_scores_gemma":[0.9992058,0.00002509304,0.0004285451,0.0001172091,0.000154909,0.00006849562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004991766,0.0002533277,0.007406415,0.0001472661,0.00002948073,0.00003462055,0.00003149512,0.000006971144,0.9900951,1.618961e-7,0.00006103305,0.001434982],"study_design_scores_gemma":[0.001944415,0.0001742831,0.01026068,0.0001954671,0.00001724592,0.00007928564,0.0001670262,0.00005867842,0.9868463,0.000002230822,0.0001770209,0.00007736311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980366,0.001471934,0.00008761488,0.0001740255,0.00007264729,0.0000636084,0.00001071325,9.765362e-7,0.0000819112],"genre_scores_gemma":[0.9985372,0.00105779,0.0001492372,0.00004853573,0.0001389607,0.000001076082,0.00003616272,0.000006584891,0.00002447108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00324877,"threshold_uncertainty_score":0.3905268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00760972967771946,"score_gpt":0.2506375910902854,"score_spread":0.2430278614125659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}