{"id":"W3130683366","doi":"10.1158/1078-0432.ccr-20-3365","title":"Mutations in the IFNγ-JAK-STAT Pathway Causing Resistance to Immune Checkpoint Inhibitors in Melanoma Increase Sensitivity to Oncolytic Virus Treatment","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; McGill University; McGill University Health Centre","funders":"Terry Fox Research Institute; Canadian Cancer Society","keywords":"Oncolytic virus; Melanoma; Cancer research; Vesicular stomatitis virus; Herpes simplex virus; Biology; Immune checkpoint; RNA interference; Virology; Immune system; Immunology; Medicine; Virus; Immunotherapy; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001143587,0.000207961,0.0002197551,0.0002818378,0.0001045523,0.000248191,0.00009971737,0.0002293354,0.001625948],"category_scores_gemma":[0.0001683894,0.0001069244,0.0002492877,0.0001325927,0.0001205249,0.00009339995,0.0001156581,0.000332449,0.0002992926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002203846,"about_ca_system_score_gemma":0.000115702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004258675,"about_ca_topic_score_gemma":0.0005549359,"domain_scores_codex":[0.9998926,0.00001356435,0.0000129802,0.00002881421,0.0000345996,0.00001740091],"domain_scores_gemma":[0.9998865,0.00002953692,0.00003818138,0.00001283392,0.00001285643,0.0000200714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001220482,0.00003446857,0.00385696,0.00002398202,0.00001274079,0.000123269,0.00001016679,0.0001998856,0.9935195,0.00004327424,0.00004186861,0.002011851],"study_design_scores_gemma":[0.00003464521,0.0006523081,0.07231785,0.00001399463,0.0000619256,0.003446224,0.00004995518,0.003352542,0.9179828,0.0001011424,0.001979611,0.000007059158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977187,0.0004269845,0.0008669631,0.00002677534,0.000008083682,0.00002064181,0.0002455578,0.00004705734,0.0006393207],"genre_scores_gemma":[0.9987503,0.0001382206,0.0005573599,0.00001513617,0.000001705852,0.000007477315,0.0001630002,0.000007032639,0.0003598178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625948,"threshold_uncertainty_score":0.005439341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.189687474134231,"score_gpt":0.5040336254214045,"score_spread":0.3143461512871735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}