{"id":"W3130741371","doi":"10.21203/rs.3.rs-235272/v1","title":"COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Advanced Research Projects Agency; Defense Advanced Research Projects Agency; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit van Amsterdam; JPB Foundation; Fondation pour la Recherche Médicale; Open Philanthropy Project; Amsterdam University Medical Centers; Icahn School of Medicine at Mount Sinai; Bill and Melinda Gates Foundation","keywords":"Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Neutralizing antibody; Antibody; 2019-20 coronavirus outbreak; Sars virus; Medicine; Immunology; Virus; Outbreak; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.007195697,0.0008101019,0.001865254,0.001977078,0.0003082771,0.0006409273,0.00149465,0.001784147,0.00003604195],"category_scores_gemma":[0.003723893,0.0007683313,0.0007844025,0.002335983,0.0007113226,0.0003401153,0.004249587,0.0110929,0.0001888451],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001249416,"about_ca_system_score_gemma":0.006881329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003391436,"about_ca_topic_score_gemma":0.002097873,"domain_scores_codex":[0.98704,0.001747673,0.001460146,0.002616282,0.004469474,0.002666405],"domain_scores_gemma":[0.9930618,0.001245682,0.0002048282,0.003037912,0.002197386,0.0002523301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005187331,0.005688063,0.123552,0.03016414,0.001035061,0.01937559,0.003153616,0.0007039149,0.7819545,0.001033427,0.002871999,0.02528033],"study_design_scores_gemma":[0.01542488,0.00337459,0.03980055,0.04488448,0.0001492841,0.0002308279,0.002369097,0.1571289,0.683188,0.01919508,0.03078527,0.003468946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705289,0.004743898,0.000970914,0.001500456,0.0003082259,0.007541282,0.00007127815,0.000267297,0.01406773],"genre_scores_gemma":[0.9901951,0.000474892,0.0009737955,0.005300659,0.0008461529,0.001653569,0.000237418,0.0002544958,0.00006389845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156425,"threshold_uncertainty_score":0.9995117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3053744805673506,"score_gpt":0.5153849650059632,"score_spread":0.2100104844386126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}