{"id":"W3130741371","doi":"10.21203/rs.3.rs-235272/v1","title":"COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Institute of Allergy and Infectious Diseases; Advanced Research Projects Agency; Defense Advanced Research Projects Agency; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institutes of Health; Universiteit van Amsterdam; JPB Foundation; Fondation pour la Recherche Médicale; Open Philanthropy Project; Amsterdam University Medical Centers; Icahn School of Medicine at Mount Sinai; Bill and Melinda Gates Foundation","keywords":"Virology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Neutralizing antibody; Antibody; 2019-20 coronavirus outbreak; Sars virus; Medicine; Immunology; Virus; Outbreak; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004946532,0.001028249,0.0007776164,0.0007563392,0.0003332603,0.0005572161,0.0005158937,0.0008074963,0.003647493],"category_scores_gemma":[0.0004064908,0.0002388255,0.0006593324,0.0003175848,0.0004380886,0.000501051,0.0002450957,0.002249834,0.0007283186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005416429,"about_ca_system_score_gemma":0.0007419406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001329065,"about_ca_topic_score_gemma":0.001638691,"domain_scores_codex":[0.9996349,0.00005397147,0.00002414806,0.00005562117,0.0000774838,0.0001538798],"domain_scores_gemma":[0.999676,0.00004169419,0.00006825523,0.00004614655,0.00005736977,0.0001105557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01828878,0.006922674,0.001169007,0.0002325579,0.0001163226,0.0002407207,0.0001085628,0.0006688689,0.9544085,0.0006130146,0.002529519,0.0147016],"study_design_scores_gemma":[0.001676913,0.04024648,0.01049367,0.00004878824,0.0002202844,0.0006304627,0.0001500913,0.002079682,0.937002,0.0004975931,0.006907852,0.00004607536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892601,0.001866511,0.001790204,0.0005446292,0.0004069522,0.0001787878,0.001890509,0.0002216043,0.003840702],"genre_scores_gemma":[0.9715933,0.002860505,0.003321205,0.0003686139,0.0001416265,0.0002978379,0.005145347,0.00007184836,0.01619974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003647493,"threshold_uncertainty_score":0.01220214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3053744805673506,"score_gpt":0.5153849650059632,"score_spread":0.2100104844386126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}