{"id":"W3130745660","doi":"10.1158/1538-7445.sabcs20-ps14-07","title":"Abstract PS14-07: Ribociclib + letrozole in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2−) advanced breast cancer (ABC) and central nervous system metastases: Subgroup analysis of the phase IIIb CompLEEment-1 trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital","funders":"","keywords":"Medicine; Breast cancer; Internal medicine; Letrozole; Goserelin; Metastatic breast cancer; Tolerability; Oncology; Cancer; Population; Adverse effect; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001871147,0.0009736426,0.001824347,0.0004051033,0.0002322391,0.0009019473,0.0005117533,0.0007013341,0.002998486],"category_scores_gemma":[0.001691947,0.0002286786,0.0039438,0.0005576342,0.0002984853,0.0004207188,0.0004186516,0.001167738,0.0003227339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006324569,"about_ca_system_score_gemma":0.00107947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147789,"about_ca_topic_score_gemma":0.004989338,"domain_scores_codex":[0.9991766,0.0004157296,0.00008577298,0.0001428254,0.00007130128,0.0001078045],"domain_scores_gemma":[0.9993944,0.0001914234,0.0001497469,0.00009482056,0.00004881186,0.0001207395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8611708,0.001571748,0.04668412,0.001927256,0.02759058,0.0003010727,0.0001272849,0.002276845,0.01080243,0.0002778048,0.006672701,0.04059735],"study_design_scores_gemma":[0.510673,0.09027314,0.3064971,0.0004451457,0.06348416,0.001124752,0.0004393563,0.006123011,0.004837604,0.001625444,0.01431544,0.0001617327],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819149,0.009701156,0.0004308501,0.0005886271,0.0001453669,0.0008023289,0.004518768,0.00004892324,0.001849083],"genre_scores_gemma":[0.9898536,0.001339638,0.0004268914,0.0005025284,0.0001619548,0.0005726985,0.005987606,0.00001416428,0.001140941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002998486,"threshold_uncertainty_score":0.01003087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512929365736709,"score_gpt":0.3655856933504026,"score_spread":0.3304563996930355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}