{"id":"W3130745660","doi":"10.1158/1538-7445.sabcs20-ps14-07","title":"Abstract PS14-07: Ribociclib + letrozole in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2−) advanced breast cancer (ABC) and central nervous system metastases: Subgroup analysis of the phase IIIb CompLEEment-1 trial","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grand River Hospital","funders":"","keywords":"Medicine; Breast cancer; Internal medicine; Letrozole; Goserelin; Metastatic breast cancer; Tolerability; Oncology; Cancer; Population; Adverse effect; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000520196,0.000495925,0.001411205,0.0005255964,0.0004317586,0.00007572395,0.0003908507,0.0001454549,0.001455832],"category_scores_gemma":[0.0001329087,0.0003651318,0.0002916956,0.002920779,0.0008753813,0.0004669665,0.0002450425,0.0009936423,0.000004152464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002413776,"about_ca_system_score_gemma":0.00083287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006171711,"about_ca_topic_score_gemma":0.002284981,"domain_scores_codex":[0.9943888,0.0008103529,0.0009165364,0.001025014,0.001666837,0.001192436],"domain_scores_gemma":[0.9962884,0.0003631201,0.0005082457,0.0007066469,0.001709347,0.0004242246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.30133,0.006311573,0.3955124,0.001767826,0.01760483,0.0001500549,0.008956777,0.001174508,0.1822582,0.0005941545,0.0007437561,0.08359596],"study_design_scores_gemma":[0.08533453,0.001180517,0.8863574,0.0008756565,0.00074296,0.000005005796,0.003158864,0.00005117402,0.02158157,0.00001352003,0.0002538801,0.0004449389],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884441,0.001953597,0.00004318444,0.0007666053,0.0002150776,0.002418806,0.006016886,0.0000414513,0.000100231],"genre_scores_gemma":[0.9978868,0.0003075398,0.0001852021,0.00009049815,0.0002493901,0.0006182885,0.000468353,0.00008608161,0.0001077964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.490845,"threshold_uncertainty_score":0.9998801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512929365736709,"score_gpt":0.3655856933504026,"score_spread":0.3304563996930355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}