{"id":"W3130783073","doi":"10.1038/s41422-020-00461-x","title":"TDP-43 triggers immune response via mitochondrial DNA release","year":2021,"lang":"en","type":"letter","venue":"Cell Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canada Research Chairs","keywords":"Biology; Mitochondrial DNA; Immune system; DNA; Computational biology; Mitochondrion; Cell biology; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001604768,0.0005207079,0.0005611537,0.00112347,0.0008603503,0.0006881873,0.001412311,0.0008904636,0.00334127],"category_scores_gemma":[0.004652126,0.0005352276,0.0003891287,0.001545538,0.000363093,0.0002303114,0.0005176687,0.005986655,0.004100916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182507,"about_ca_system_score_gemma":0.001093369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000114069,"about_ca_topic_score_gemma":0.000001429754,"domain_scores_codex":[0.9837359,0.008914317,0.0008393219,0.001886505,0.003251896,0.001372115],"domain_scores_gemma":[0.9928576,0.004174989,0.0002532537,0.00194261,0.0004597845,0.0003117437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004035449,0.00004072344,2.599662e-8,0.00006211671,0.000001929352,0.003701397,0.00004602053,0.000006137657,0.5537595,0.00002989465,0.4417534,0.0001953192],"study_design_scores_gemma":[0.0005565307,0.0001457838,6.920957e-7,0.00002398496,0.000005947207,0.00004869417,0.000007211862,0.0001830996,0.5304933,0.00009997282,0.4681863,0.0002484158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.08229414,0.0003898958,0.0005168449,0.8832315,0.009417156,0.003499174,0.0001995129,0.0006490978,0.0198027],"genre_scores_gemma":[0.0111541,0.0008464269,0.0003489532,0.456831,0.009641692,0.0004790545,0.0003362701,0.000531846,0.5198306],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.500028,"threshold_uncertainty_score":0.9997099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047522271170838,"score_gpt":0.336309449631815,"score_spread":0.2315572225147312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}