{"id":"W3130816366","doi":"10.1016/j.exphem.2020.09.040","title":"3019 – CRISPR-BASED ENGINEERING OF A REPORTER ALLELE DEMONSTRATES THAT HLF EXPRESSION DEFINES THE HUMAN HAEMATOPOIETIC STEM CELL STATE","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Stem cell; Haematopoiesis; Biology; Transplantation; Reporter gene; Progenitor cell; Cell biology; Blood cell; Immunology; Genetics; Gene; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006349663,0.0002130171,0.0002659328,0.00002636102,0.00006307258,0.00001237094,0.0002075256,0.0001036906,0.00003548001],"category_scores_gemma":[0.000006626856,0.0001709832,0.0001170781,0.00005709083,0.00007364019,0.000003990993,0.0001235061,0.00008291518,0.000004155564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006303179,"about_ca_system_score_gemma":0.00002393964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007191182,"about_ca_topic_score_gemma":0.000002136455,"domain_scores_codex":[0.9989341,0.00003533042,0.000326177,0.0003314814,0.0001199767,0.0002529147],"domain_scores_gemma":[0.9994377,0.00001951769,0.0001166384,0.0003105454,0.00002407505,0.00009146625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003028393,0.00007154469,0.002178374,0.0001108303,0.00002057472,0.00002090134,0.0003399769,0.001336314,0.9947119,0.00008859171,0.001072275,0.00001837358],"study_design_scores_gemma":[0.0004435458,0.0002143136,0.0001573788,0.00002115574,0.00001010569,0.00006608506,0.0005868475,0.0008751685,0.9964729,0.000004092174,0.0009673062,0.000181078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981464,0.007409113,0.01039639,0.0001965461,0.00009014799,0.0002365457,0.000007128204,0.00003377624,0.0001664051],"genre_scores_gemma":[0.9986362,0.00001278536,0.0009886841,0.0001548083,0.00003907303,0.00004963152,0.00003438056,0.00003522826,0.00004914286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01717232,"threshold_uncertainty_score":0.6972492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650929455531849,"score_gpt":0.2852648939324119,"score_spread":0.2687555993770935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}