{"id":"W3130816366","doi":"10.1016/j.exphem.2020.09.040","title":"3019 – CRISPR-BASED ENGINEERING OF A REPORTER ALLELE DEMONSTRATES THAT HLF EXPRESSION DEFINES THE HUMAN HAEMATOPOIETIC STEM CELL STATE","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Stem cell; Haematopoiesis; Biology; Transplantation; Reporter gene; Progenitor cell; Cell biology; Blood cell; Immunology; Genetics; Gene; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999034,0.0002044802,0.0002001008,0.0002777864,0.0003213517,0.0005152355,0.0003386156,0.000519213,0.007129511],"category_scores_gemma":[0.0001685712,0.0001774134,0.0002371387,0.0001614659,0.0005115433,0.0002048517,0.0002934887,0.000861059,0.00257226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004220846,"about_ca_system_score_gemma":0.0004481968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002211306,"about_ca_topic_score_gemma":0.003569495,"domain_scores_codex":[0.9997774,0.00002225917,0.00002300119,0.00005785693,0.00007421541,0.00004527387],"domain_scores_gemma":[0.9998272,0.00004012364,0.00003095846,0.00003213468,0.0000137681,0.0000557315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005247327,0.00002275318,0.000160317,0.000009380802,0.000003013265,0.00007119913,0.00002101155,0.00008786337,0.9960387,0.0009641956,0.000239136,0.002329958],"study_design_scores_gemma":[0.00001020316,0.00003293212,0.002133606,0.000003437682,0.000003736921,0.0002786129,0.00002080936,0.0008989092,0.9831774,0.0001450868,0.01328911,0.000006211281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8934941,0.0004456886,0.06707989,0.0007976146,0.0002031442,0.0001561649,0.00516771,0.001546966,0.03110863],"genre_scores_gemma":[0.9510086,0.0002537595,0.01802114,0.0003239912,0.00001845193,0.00007387865,0.003857994,0.0003916731,0.02605054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007129511,"threshold_uncertainty_score":0.02385062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01650929455531849,"score_gpt":0.2852648939324119,"score_spread":0.2687555993770935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}