{"id":"W3130817728","doi":"10.14814/phy2.14745","title":"Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Calgary; McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research; Shriners Hospitals for Children","keywords":"Osteoclast; Bone marrow; RANKL; Erythropoiesis; Bone resorption; Haematopoiesis; Microvesicles; Cancer research; Chemistry; Osteolysis; Cell biology; Immunology; Endocrinology; Internal medicine; Medicine; Biology; Anemia; Stem cell; In vitro; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002109023,0.000231731,0.000184364,0.0001622129,0.00008764438,0.0002864818,0.00007303345,0.0001988222,0.001118972],"category_scores_gemma":[0.0001527718,0.0000958734,0.0001824409,0.0001081352,0.0001585056,0.0001946531,0.0002566213,0.0003459512,0.0001663373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009717849,"about_ca_system_score_gemma":0.00008678113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009322519,"about_ca_topic_score_gemma":0.0001623729,"domain_scores_codex":[0.9998534,0.00003291291,0.00001463034,0.00002836594,0.00004011906,0.00003048851],"domain_scores_gemma":[0.9999192,0.00001561535,0.00002547092,0.000009266927,0.00000821131,0.00002222973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527812,0.00002028079,0.0006121097,0.00004304586,0.000006005089,0.0001379414,0.00001871489,0.0000144055,0.9976693,0.00009053403,0.00005146214,0.001183433],"study_design_scores_gemma":[0.00005382825,0.0004383956,0.03212176,0.00001618912,0.00002447773,0.001608665,0.00005285048,0.0005319309,0.9613346,0.0001109137,0.003700341,0.000005877178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917437,0.003665344,0.003083431,0.0001041078,0.0000250686,0.00002595094,0.0003059132,0.00004805817,0.0009982612],"genre_scores_gemma":[0.9956191,0.001014238,0.001754804,0.00004875521,0.00001305833,0.00001682827,0.0003417613,0.000006723534,0.001184655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001118972,"threshold_uncertainty_score":0.003743291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04829637220706388,"score_gpt":0.2818855273911116,"score_spread":0.2335891551840477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}