{"id":"W3130817728","doi":"10.14814/phy2.14745","title":"Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation","year":2021,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Calgary; McGill University; Shriners Hospitals for Children - Canada","funders":"Canadian Institutes of Health Research; Shriners Hospitals for Children","keywords":"Osteoclast; Bone marrow; RANKL; Erythropoiesis; Bone resorption; Haematopoiesis; Microvesicles; Cancer research; Chemistry; Osteolysis; Cell biology; Immunology; Endocrinology; Internal medicine; Medicine; Biology; Anemia; Stem cell; In vitro; microRNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000949237,0.0001653216,0.0005371335,0.00004956398,0.00006543482,0.000005721865,0.00003244029,0.0001669082,0.0006654008],"category_scores_gemma":[0.0008375227,0.0001171921,0.000241575,0.0002153645,0.000125391,0.0001303186,0.00006263241,0.0001952696,0.00002291698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004581274,"about_ca_system_score_gemma":0.0001259415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005602487,"about_ca_topic_score_gemma":0.000001090537,"domain_scores_codex":[0.9986144,0.0001075539,0.0004406741,0.0003688722,0.0002439805,0.0002244706],"domain_scores_gemma":[0.9987593,0.0001155932,0.0003723121,0.0003665382,0.000251634,0.0001345637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006074037,0.0005392668,0.0009177449,0.0002711622,0.0000702129,0.001149514,0.0002058619,0.00001118902,0.9911763,0.0001454157,0.001174577,0.003731352],"study_design_scores_gemma":[0.000756312,0.0008502431,0.1217819,0.0001592892,0.00009816139,0.001947908,0.0005343347,0.00008611527,0.8695401,0.002529583,0.001527161,0.0001888891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951284,0.0001063083,0.0001210724,0.0003441522,0.0002097987,0.0002987981,0.000006126448,0.00008264781,0.003702683],"genre_scores_gemma":[0.9982561,0.00007635255,0.000503843,0.0003753727,0.0001102898,0.00003812269,0.00018883,0.00001114361,0.000439919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1216362,"threshold_uncertainty_score":0.7285671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04829637220706388,"score_gpt":0.2818855273911116,"score_spread":0.2335891551840477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}