{"id":"W3130860671","doi":"10.1093/genetics/iyab003","title":"Comprehensive genetic analysis of adhesin proteins and their role in virulence of<i>Candida albicans</i>","year":2021,"lang":"en","type":"article","venue":"Genetics","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph; Canadian Institutes of Health Research; John S. Dunn Foundation; Welch Foundation","keywords":"Virulence; Biology; Bacterial adhesin; Candida albicans; Genetics; Microbiology; Genetic analysis; Fungal protein; Gene; Saccharomyces cerevisiae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006384616,0.00009826263,0.0004698859,0.0001089242,0.00001474041,0.000003520207,0.00005304542,0.00006216176,0.00006352489],"category_scores_gemma":[0.00004669104,0.00008432403,0.0001009592,0.0006634975,0.0001669406,0.00001026433,0.00004586128,0.00008046193,6.600671e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001667345,"about_ca_system_score_gemma":0.00014027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009049635,"about_ca_topic_score_gemma":0.000989231,"domain_scores_codex":[0.999117,0.00004470366,0.0003174086,0.0002304271,0.0001509454,0.000139515],"domain_scores_gemma":[0.9992242,0.000067824,0.00008120832,0.0003618697,0.0002020585,0.0000628563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005770896,0.0001003507,0.5699136,0.0001312797,0.0001812241,0.00001233867,0.0004938017,0.0001228354,0.4240501,0.00001349755,0.000005355148,0.00491798],"study_design_scores_gemma":[0.0003267266,0.0001112502,0.8399818,0.00005655854,0.0002613637,0.000002913818,0.0009281405,0.001174526,0.1566987,0.0001020225,0.0002925272,0.00006340176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912003,0.007912424,0.0003648159,0.00006264637,0.00001016316,0.0001801064,0.0000421894,0.0000039174,0.0002234195],"genre_scores_gemma":[0.9955074,0.001116466,0.003182577,0.00009378955,0.0000103401,0.000004723908,0.00001163547,0.000007046725,0.00006599881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2700682,"threshold_uncertainty_score":0.3438634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343582347360148,"score_gpt":0.2580186426319505,"score_spread":0.244582819158349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}