{"id":"W3130957921","doi":"10.1016/j.bpj.2020.11.1195","title":"Dynamic FLNa and FilGAP Binding Is Required for Contractile Mechanotransduction Response to Shear-Stress","year":2021,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"FLNA; Mechanotransduction; Filamin; Shear stress; Cell biology; Biophysics; Chemistry; Materials science; Cytoskeleton; Cell; Biology; Biochemistry; Composite material","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002328142,0.0003302522,0.0004667384,0.0003142381,0.000930297,0.001101863,0.000767106,0.0009881509,0.004184161],"category_scores_gemma":[0.0007040375,0.0005185958,0.0003428065,0.0001374444,0.0006219462,0.0007074727,0.0007628283,0.001200248,0.001900245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007950651,"about_ca_system_score_gemma":0.0004504371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001552443,"about_ca_topic_score_gemma":0.003511247,"domain_scores_codex":[0.9996058,0.00002588435,0.00003536446,0.0001101847,0.0001239611,0.00009874964],"domain_scores_gemma":[0.9993142,0.0001243064,0.000174888,0.00008800834,0.00006109674,0.0002374868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001315019,0.00002511274,0.000233172,0.00001772525,0.000003928839,0.00007738484,0.000012647,0.00004431442,0.9985449,0.0002174084,0.00007022665,0.0006216215],"study_design_scores_gemma":[0.00004359995,0.00005611029,0.02751303,0.00001615444,0.00001435064,0.0007109601,0.00008923337,0.004242087,0.9633231,0.0003644676,0.003600712,0.00002620171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904366,0.0008047397,0.005768243,0.0004720752,0.0001008789,0.00002352672,0.0004380003,0.0002137036,0.00174238],"genre_scores_gemma":[0.993921,0.00009293731,0.002637869,0.0001719447,0.00001531287,0.00002790774,0.0005171603,0.00008522545,0.002530759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004184161,"threshold_uncertainty_score":0.01399738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135959360150049,"score_gpt":0.2997946027999664,"score_spread":0.2884350091984659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}