{"id":"W3131013716","doi":"10.1038/s41434-021-00236-y","title":"AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge","year":2021,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Clostridium difficile toxin A; Clostridium difficile; Clostridium difficile toxin B; Microbiology; Antibiotics; Antibody; Monoclonal antibody; Enterotoxin; Toxin; Virology; Biology; Enterocolitis; Immunology; Medicine; Gene; Pathology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396249,0.0003756697,0.0003300105,0.0002555036,0.0002227315,0.0004801844,0.0001706188,0.0005815685,0.001694295],"category_scores_gemma":[0.0001988351,0.0001566597,0.0002816393,0.0001188379,0.0004335028,0.000310763,0.0001266572,0.00113522,0.0003758293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005789577,"about_ca_system_score_gemma":0.0005211247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001751465,"about_ca_topic_score_gemma":0.002491417,"domain_scores_codex":[0.9997193,0.00003205317,0.0000193647,0.00005206545,0.00007203488,0.0001052562],"domain_scores_gemma":[0.9998727,0.00001853122,0.00003178162,0.00001155592,0.00001730117,0.00004810699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001108963,0.0002268092,0.0002031633,0.00005186653,0.00001313113,0.00004714626,0.00002760165,0.0001616571,0.9928879,0.0002787859,0.0003417149,0.004651306],"study_design_scores_gemma":[0.000315266,0.003952061,0.004683999,0.0000154498,0.0000648417,0.0004084985,0.00006941812,0.002156439,0.9835569,0.000122954,0.004639783,0.00001439024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910166,0.001171955,0.004090421,0.0003840155,0.0001860275,0.00006571881,0.0003283998,0.0002406229,0.002516109],"genre_scores_gemma":[0.9926709,0.0004450238,0.002465573,0.00009048805,0.00002626,0.00003502085,0.0003080723,0.00002350996,0.003935119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001751465,"threshold_uncertainty_score":0.005667984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04693519656594888,"score_gpt":0.2978495359796029,"score_spread":0.250914339413654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}