{"id":"W3131016558","doi":"10.1101/2021.02.21.432180","title":"Restoration of BDNF-TrkB signaling rescues deficits in a mouse model of SCA6","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Tropomyosin receptor kinase B; Neurotrophic factors; Motor coordination; Neuroscience; Spinocerebellar ataxia; Brain-derived neurotrophic factor; Ataxia; Cerebellum; Psychology; Medicine; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002847399,0.0007762941,0.0006894548,0.0009615179,0.0003676017,0.0003895639,0.000559565,0.001060762,0.002988447],"category_scores_gemma":[0.0001242185,0.0003071873,0.000552594,0.0002703394,0.0005114073,0.00030171,0.0003407435,0.001737766,0.001114952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003715269,"about_ca_system_score_gemma":0.0002952131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002240937,"about_ca_topic_score_gemma":0.005275528,"domain_scores_codex":[0.9997154,0.00003567423,0.00004133992,0.000067604,0.00008845362,0.00005156075],"domain_scores_gemma":[0.9996678,0.0000232418,0.000104055,0.00002789971,0.00003094706,0.0001460435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002287782,0.0001297071,0.0001118216,0.00005260769,0.00001095175,0.0001201338,0.00003139522,0.0001041613,0.9969506,0.0001290977,0.0001928573,0.001937858],"study_design_scores_gemma":[0.0001455734,0.001460219,0.004908793,0.00004805972,0.00004181677,0.0005516623,0.00008213541,0.002024889,0.9849129,0.0001380587,0.005667436,0.00001841125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846831,0.00206011,0.006241989,0.0005900597,0.0001803345,0.0001017194,0.002582176,0.0009517257,0.002608821],"genre_scores_gemma":[0.952601,0.002063687,0.01176197,0.0002201369,0.00005755296,0.0001931763,0.002440435,0.0003172714,0.03034491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002988447,"threshold_uncertainty_score":0.009997368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04100668195404923,"score_gpt":0.2473929921632047,"score_spread":0.2063863102091554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}