{"id":"W3131054438","doi":"10.1038/s41590-021-00862-z","title":"A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Ministry of Education, Culture, Sports, Science and Technology; Crohn's and Colitis Foundation; Japan Society for the Promotion of Science; Crohn's and Colitis Foundation of America; U.S. Department of Veterans Affairs; Fundación Ramón Areces","keywords":"CD22; Lymphocyte homing receptor; Endocytosis; Cell biology; High endothelial venules; Homing (biology); Biology; B cell; Integrin; CD49b; Protein tyrosine phosphatase; Lymphocyte; Molecular biology; T cell; Cell adhesion; Cell; Immunology; Phosphorylation; Biochemistry; Immune system; Antigen-presenting cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000209468,0.0002420092,0.0002816893,0.00006543519,0.0000816856,0.00003048163,0.0002140097,0.0007799546,0.00006098807],"category_scores_gemma":[0.0004947862,0.0002360058,0.00007398636,0.0001808724,0.0001668801,0.000012263,0.0003583933,0.0009257754,0.00001512521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003233274,"about_ca_system_score_gemma":0.0001395628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001503083,"about_ca_topic_score_gemma":0.0003336045,"domain_scores_codex":[0.9985688,0.0002192175,0.0002678434,0.0004938633,0.00009000945,0.0003602878],"domain_scores_gemma":[0.999088,0.00005977237,0.0001010726,0.0005726737,0.0001238561,0.00005460899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001199874,0.0002602494,0.003739072,0.00003604677,0.0001122618,0.00008994659,0.00003010151,0.000004360461,0.9782946,0.004983297,0.001600015,0.00965016],"study_design_scores_gemma":[0.002526943,0.0003841981,0.02494325,0.00002194316,0.00002971482,0.00009359315,0.00009326895,0.00001181626,0.9170923,0.00039922,0.05415285,0.0002508918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6800864,0.3180218,0.0002759446,0.0003917278,0.0005000216,0.0002410517,0.0001982023,0.00001989597,0.0002649551],"genre_scores_gemma":[0.9951311,0.001783528,0.0003357982,0.0007640686,0.00009143496,0.00006227697,0.001516399,0.00002527445,0.000290098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3162383,"threshold_uncertainty_score":0.9624036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003101919448392076,"score_gpt":0.2223490619631506,"score_spread":0.2192471425147585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}