{"id":"W3131054438","doi":"10.1038/s41590-021-00862-z","title":"A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity","year":2021,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; U.S. Department of Health and Human Services; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Ministry of Education, Culture, Sports, Science and Technology; Crohn's and Colitis Foundation; Japan Society for the Promotion of Science; Crohn's and Colitis Foundation of America; U.S. Department of Veterans Affairs; Fundación Ramón Areces","keywords":"CD22; Lymphocyte homing receptor; Endocytosis; Cell biology; High endothelial venules; Homing (biology); Biology; B cell; Integrin; CD49b; Protein tyrosine phosphatase; Lymphocyte; Molecular biology; T cell; Cell adhesion; Cell; Immunology; Phosphorylation; Biochemistry; Immune system; Antigen-presenting cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001312257,0.0004286048,0.0002089,0.0003185998,0.0002468617,0.0006463674,0.0002098645,0.0003584478,0.001168018],"category_scores_gemma":[0.0001324186,0.0002771761,0.0001734121,0.0001427653,0.0004117851,0.0003934679,0.0004503079,0.0006296581,0.0004653909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006091197,"about_ca_system_score_gemma":0.0002478385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006079418,"about_ca_topic_score_gemma":0.0007524646,"domain_scores_codex":[0.9998571,0.00001644414,0.000005652373,0.00003308113,0.00003644691,0.00005128527],"domain_scores_gemma":[0.9999048,0.000008766398,0.00002338627,0.000007407251,0.00001260161,0.00004307789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009900869,0.00001246602,0.0003851097,0.00001463764,0.000003194092,0.00007391642,0.00001400511,0.00006452247,0.9973406,0.0003177859,0.0000530377,0.001621625],"study_design_scores_gemma":[0.00002926678,0.0001653777,0.02114289,0.000005523985,0.00001842688,0.0003321433,0.00008186566,0.002458293,0.9718044,0.0004558396,0.003495717,0.00001020215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992726,0.002480996,0.001812624,0.0001790784,0.00002544837,0.00001305505,0.0001081731,0.00009600581,0.002558665],"genre_scores_gemma":[0.9963877,0.0008988602,0.0004928514,0.00004211545,0.000009605399,0.00001321268,0.0001209478,0.00001672534,0.002017955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001168018,"threshold_uncertainty_score":0.004419446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003101919448392076,"score_gpt":0.2223490619631506,"score_spread":0.2192471425147585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}