{"id":"W3131061582","doi":"10.1002/ajh.26136","title":"A <scp>Phase I</scp> dose‐escalation study of <scp>DCLL9718S</scp>, an antibody‐drug conjugate targeting <scp>C</scp>‐type lectin‐like molecule‐1 (<scp>CLL</scp>‐1) in patients with acute myeloid leukemia","year":2021,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; Jewish General Hospital; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"National Center for Advancing Translational Sciences; Genentech","keywords":"Antibody-drug conjugate; Cancer research; Myeloid leukemia; Antibody; Myeloid; Chemistry; Monoclonal antibody; Molecular biology; Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008253189,0.001669723,0.001452563,0.0006292438,0.000450803,0.001131525,0.0009194582,0.001295937,0.003939999],"category_scores_gemma":[0.0005136306,0.0006853134,0.001062124,0.0006171062,0.0008830883,0.0006167675,0.0003040301,0.003907748,0.001027491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001365754,"about_ca_system_score_gemma":0.001927386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001595516,"about_ca_topic_score_gemma":0.004066739,"domain_scores_codex":[0.9996626,0.00009572956,0.00001195475,0.00007846425,0.00007718901,0.00007397633],"domain_scores_gemma":[0.9995414,0.00006418464,0.00009044375,0.00004411459,0.00003784348,0.0002220514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3137397,0.164843,0.004492113,0.001860296,0.002209886,0.0006646257,0.000621883,0.0105034,0.2598597,0.001578339,0.0240988,0.2155283],"study_design_scores_gemma":[0.3370973,0.5997872,0.0112038,0.0001031499,0.0006160964,0.0007115377,0.00009489986,0.003606606,0.02878333,0.0006567554,0.01725756,0.00008179725],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787862,0.003335664,0.001791067,0.0009741578,0.0002637008,0.006019723,0.003009681,0.0003291582,0.005490663],"genre_scores_gemma":[0.9713965,0.003826971,0.003736462,0.001803916,0.0001455232,0.004375596,0.005249409,0.0001005134,0.009365104],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003939999,"threshold_uncertainty_score":0.01318055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007897356507361076,"score_gpt":0.2654896933773154,"score_spread":0.2575923368699544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}