{"id":"W3131061582","doi":"10.1002/ajh.26136","title":"A <scp>Phase I</scp> dose‐escalation study of <scp>DCLL9718S</scp>, an antibody‐drug conjugate targeting <scp>C</scp>‐type lectin‐like molecule‐1 (<scp>CLL</scp>‐1) in patients with acute myeloid leukemia","year":2021,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; McGill University; Jewish General Hospital; University of Alberta Hospital; Alberta Hospital Edmonton","funders":"National Center for Advancing Translational Sciences; Genentech","keywords":"Antibody-drug conjugate; Cancer research; Myeloid leukemia; Antibody; Myeloid; Chemistry; Monoclonal antibody; Molecular biology; Immunology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0008968866,0.001331667,0.002879681,0.0008566411,0.0002490293,0.0001452002,0.001268732,0.0009611596,0.0000064382],"category_scores_gemma":[0.0008219645,0.001258324,0.0005364086,0.001235861,0.0005938495,0.00007448475,0.0004239379,0.00258217,0.000008004178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752593,"about_ca_system_score_gemma":0.001482953,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002662657,"about_ca_topic_score_gemma":0.0001352642,"domain_scores_codex":[0.9919347,0.001253251,0.00237919,0.001582618,0.001197388,0.001652809],"domain_scores_gemma":[0.9912599,0.0007747457,0.004642879,0.001207554,0.001659601,0.0004553672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007498448,0.008292243,0.04965034,0.001004951,0.0136462,0.009233393,0.01446337,0.001470012,0.5527214,0.00008153295,0.3441638,0.004522936],"study_design_scores_gemma":[0.04149395,0.06675941,0.005743891,0.001403904,0.004551947,0.005216265,0.03256103,0.0004362461,0.31314,0.0003907982,0.527297,0.001005639],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930754,0.002189321,0.00121087,0.0005679134,0.001548033,0.001037076,0.0001024324,0.00003550168,0.0002334893],"genre_scores_gemma":[0.9627191,0.001516599,0.002551323,0.02767967,0.001399706,0.00007802015,0.002209867,0.0005207717,0.001324986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2395814,"threshold_uncertainty_score":0.9999434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007897356507361076,"score_gpt":0.2654896933773154,"score_spread":0.2575923368699544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}