{"id":"W3131078121","doi":"10.1158/1538-7445.sabcs20-pd2-07","title":"Abstract PD2-07: Alpelisib + letrozole in patients with <i>PIK3CA-</i>mutated, hormone-receptor positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) advanced breast cancer (ABC) previously treated with a cyclin-dependent kinase 4/6 inhibitor (CDK4/6i) + fulvestrant: BYLieve study results","year":2021,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Letrozole; Cohort; Medicine; Fulvestrant; Internal medicine; Oncology; Breast cancer; Clinical endpoint; Cancer; Gynecology; Clinical trial; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007818726,0.00120912,0.001716711,0.0007096399,0.0006506703,0.0002095175,0.0006026081,0.0003512633,0.001332568],"category_scores_gemma":[0.0002613997,0.0009673232,0.0002086095,0.002484817,0.0009552364,0.00116029,0.0002752202,0.00266604,0.00008587512],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003941634,"about_ca_system_score_gemma":0.002165559,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01033162,"about_ca_topic_score_gemma":0.006866797,"domain_scores_codex":[0.9894094,0.0009188697,0.001462879,0.002594025,0.003207596,0.002407246],"domain_scores_gemma":[0.9924681,0.0004620354,0.0006219845,0.001237441,0.004155494,0.001054962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.235341,0.01752875,0.5130695,0.0008605627,0.003875363,0.003338078,0.02112958,0.001497055,0.1574736,0.0000235736,0.001278104,0.04458485],"study_design_scores_gemma":[0.06605369,0.007034899,0.8333573,0.003050892,0.0002034803,0.00005327463,0.005590007,0.000009101493,0.08298621,0.00001762213,0.0002767561,0.001366805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984753,0.001650563,0.00001144508,0.001526635,0.0001814306,0.006219672,0.004855718,0.0002056182,0.0005958764],"genre_scores_gemma":[0.9940321,0.000572697,0.0003484502,0.0002025053,0.000529853,0.002267129,0.0008106396,0.0003544774,0.0008821646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3202878,"threshold_uncertainty_score":0.999882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02330723514965225,"score_gpt":0.3372044939661631,"score_spread":0.3138972588165109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}